Human NPTX2 Protein, His Tag (MALS verified)
分子别名(Synonym)
Neuronal pentraxin II,NP-II,NPTX2
表达区间及表达系统(Source)
Human NPTX2, His Tag (NP2-H52H6) is expressed from human 293 cells (HEK293). It contains AA Gly 16 - Leu 431 (Accession # P47972).
蛋白结构(Molecular Characterization)

This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 47.7 kDa. The protein migrates as 50-63 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
内毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
纯度(Purity)
>95% as determined by SDS-PAGE.
制剂(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重构方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存储(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.

背景(Background)
神经元五聚蛋白2(NPTX2),也称为神经元活动调节五聚蛋白,是一种分泌型糖蛋白,其特征是环状多聚体结构。在体内,NTPX2通过与跨膜蛋白神经元笔曲毒素受体(NPTXR)结合发挥各种神经作用。NPTX2被认为在传递神经递质和维持突触可塑性方面起着至关重要的作用。它还参与了α-氨基-3-羟基-5-甲基-4-异恶唑丙酸(AMPA)型谷氨酸受体在已建立的突触上的聚集,导致多巴胺能神经细胞的非凋亡细胞死亡。帕金森病(PD)组织中该基因的上调表明该蛋白可能参与PD的病理过程。
关键字: NPTX2;NPTX2蛋白;NP-II;ACRO;百普赛斯;
百普赛斯集团ACROBiosystems Group(股票代码:301080)是成立于2010年的跨国生物科技公司,是为全球生物医药、健康产业领域提供关键生物试剂产品及解决方案的行业平台型基石企业。2021年在创业板上市。百普赛斯集团业务遍布全球,横跨亚洲、北美洲、欧洲,在中国、美国、瑞士等12个城市设有办公室、研发中心及生产基地。目前累计服务客户超6000家,与全球Top 20医药企业均建立了长期、稳定的合作伙伴关系。集团旗下拥有品牌ACROBiosystems百普赛斯、bioSeedin柏思荟、Condense Capital垦拓资本和ACRODiagnostics百斯医学等。