Human LAMP5 / BAD-LAMP Protein, His Tag
分子别名(Synonym)
LAMP5,BAD-LAMP
表达区间及表达系统(Source)
Human LAMP5, His Tag (LA5-H52H9) is expressed from human 293 cells (HEK293). It contains AA Glu 30 - Glu 235 (Accession # Q9UJQ1-1).
Predicted N-terminus: Glu 30
蛋白结构(Molecular Characterization)

This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 25 kDa. The protein migrates as 31-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
内毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
纯度(Purity)
>95% as determined by SDS-PAGE.
制剂(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.
Contact us for customized product form or formulation.
重构方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存储(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.

背景(Background)
LAMP(溶酶体相关膜蛋白)代表了一个主要存在于溶酶体膜上的糖基化蛋白家族,其表达在不同组织中可能有所不同,表明功能分离。LAMP5在MLL-r白血病中高度特异性表达。LAMP5是致癌MLL融合蛋白的直接靶点。LAMP5耗竭显著抑制了白血病细胞在体外和体内的生长。功能研究表明,LAMP-5是MLL-r白血病先天免疫途径的新型调节剂。LAMP5的下调导致NF-κB信号传导受到抑制,Toll样受体/白细胞介素1受体激活下游的1型干扰素信号传导激活增加。
关键字: LAMP5;LAMP5蛋白;LAMP5重组蛋白;ACRO;百普赛斯;
百普赛斯集团ACROBiosystems Group(股票代码:301080)是成立于2010年的跨国生物科技公司,是为全球生物医药、健康产业领域提供关键生物试剂产品及解决方案的行业平台型基石企业。2021年在创业板上市。百普赛斯集团业务遍布全球,横跨亚洲、北美洲、欧洲,在中国、美国、瑞士等12个城市设有办公室、研发中心及生产基地。目前累计服务客户超6000家,与全球Top 20医药企业均建立了长期、稳定的合作伙伴关系。集团旗下拥有品牌ACROBiosystems百普赛斯、bioSeedin柏思荟、Condense Capital垦拓资本和ACRODiagnostics百斯医学等。