HTT产品信息
英文名称:Huntingtin
中文名称:亨廷顿蛋白
靶点别称:HTT
物种:Human
标签:His Tag & MBP Tag
属性:Protein
标记:Unconjugated
表达区间及表达系统(Source)
Human HTT, MBP,His Tag (HTT-H51M5) is expressed from E. coli cells. It contains AA Met 1 - Glu 82 (Accession # P42858-1).
Predicted N-terminus: Met
蛋白结构(Molecular Characterization)

This protein carries a MBP tag at the N-terminus and a polyhistidine tag at the C-terminus
The protein has a calculated MW of 52.7 kDa. The protein migrates as 60-63 kDa under reducing (R) condition (SDS-PAGE).
内毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
纯度(Purity)
>95% as determined by SDS-PAGE.
制剂(Formulation)
Lyophilized from 0.22 μm filtered solution in 20 mM HEPES, 150 mM NaCl, pH7.5 with trehalose as protectant.
Contact us for customized product form or formulation.
重构方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存储(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.

背景(Background)
亨廷顿蛋白是由HTT基因编码的蛋白质。亨廷顿蛋白(Htt)中的常染色体显性突变是亨廷顿氏病(HD)的病因。在HD中,蛋白质N端序列中的聚谷氨酰胺(polyQ)结构域扩展到超过36个谷氨酰胺的阈值。突变型polyQ扩增与发病年龄呈负相关。
关键字: Huntingtin;HTT蛋白;HTT重组蛋白;ACRO;百普赛斯;
百普赛斯集团ACROBiosystems Group(股票代码:301080)是成立于2010年的跨国生物科技公司,是为全球生物医药、健康产业领域提供关键生物试剂产品及解决方案的行业平台型基石企业。2021年在创业板上市。百普赛斯集团业务遍布全球,横跨亚洲、北美洲、欧洲,在中国、美国、瑞士等12个城市设有办公室、研发中心及生产基地。目前累计服务客户超6000家,与全球Top 20医药企业均建立了长期、稳定的合作伙伴关系。集团旗下拥有品牌ACROBiosystems百普赛斯、bioSeedin柏思荟、Condense Capital垦拓资本和ACRODiagnostics百斯医学等。