ILDR2产品信息
英文名称:Immunoglobulin-like domain-containing receptor 2
中文名称:免疫球蛋白样结构域受体2
靶点别称:ILDR2,C1orf32
物种:Human
标签:Fc Tag
属性:Protein
标记:Unconjugated
表达区间及表达系统(Source)
Human ILDR2, Fc Tag (IL2-H5259) is expressed from human 293 cells (HEK293). It contains AA Leu 21 - Glu 186 (Accession # Q71H61-1).
Predicted N-terminus: Leu 21
蛋白结构(Molecular Characterization)

This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 45.1 kDa. The protein migrates as 45-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
内毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
纯度(Purity)
>95% as determined by SDS-PAGE.
制剂(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重构方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存储(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.

背景(Background)
ILDR2属于免疫球蛋白超家族。可能参与脂质稳态和ER应激途径。ILDR2是一种新型的B7样蛋白,具有强大的T细胞抑制活性,在免疫细胞和免疫特权和炎症组织中表达。由ILDR2胞外结构域和Fc片段组成的融合蛋白与活化T细胞上的推定对应物结合,在胶原诱导的关节炎模型中显示出有益作用,并消除了巨噬细胞和细胞因子刺激的T细胞自体滑膜样共培养物中促炎细胞因子和趋化因子的产生。总之,这些发现表明ILDR2是一种新的T细胞负调控因子,在免疫相关疾病的发展中具有潜在作用,包括自身免疫和癌症。
关键字: ILDR2;ILDR2蛋白;ILDR2重组蛋白;ACRO;百普赛斯;
百普赛斯集团ACROBiosystems Group(股票代码:301080)是成立于2010年的跨国生物科技公司,是为全球生物医药、健康产业领域提供关键生物试剂产品及解决方案的行业平台型基石企业。2021年在创业板上市。百普赛斯集团业务遍布全球,横跨亚洲、北美洲、欧洲,在中国、美国、瑞士等12个城市设有办公室、研发中心及生产基地。目前累计服务客户超6000家,与全球Top 20医药企业均建立了长期、稳定的合作伙伴关系。集团旗下拥有品牌ACROBiosystems百普赛斯、bioSeedin柏思荟、Condense Capital垦拓资本和ACRODiagnostics百斯医学等。