Human FKBP4 / FKBP52 Protein, His,PA Tag
分子别名(Synonym)
FKBP4,FKBP52
表达区间及表达系统(Source)
Human FKBP4, His,PA Tag (FK4-H52Q3) is expressed from human 293 cells (HEK293). It contains AA Met 1 - Ala 459 (Accession # AAH01786).
Predicted N-terminus: Met 1
蛋白结构(Molecular Characterization)

This protein carries a polyhistidine tag at the C-terminus, followed by a PA tag, and has a calculated MW of 55.1 kDa. The reducing (R) protein migrates as 60 kDa in SDS-PAGE.
内毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
纯度(Purity)
>95% as determined by SDS-PAGE.
制剂(Formulation)
Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, pH7.5 with trehalose as protectant.
Contact us for customized product form or formulation.
重构方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存储(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.

背景(Background)
肽基脯氨酰顺反异构酶FKBP4(PPIase FKBP4)也称为亲免疫蛋白FKBP52。FKBP4是亲免疫蛋白家族的成员,在免疫调节和涉及蛋白质折叠和运输的基本细胞过程中发挥作用。FKBP4与FK506结合蛋白1A(FKBP1A)在结构和功能上具有高度相似性,但与FKBP1A不同,该蛋白与FK506复合时没有免疫抑制活性。FKBP4与干扰素调节因子-4相互作用,在B和T淋巴细胞的免疫调节基因表达中起着重要作用。
关键字: FKBP4;FKBP4蛋白;FKBP4重组蛋白;ACRO;百普赛斯;
百普赛斯集团ACROBiosystems Group(股票代码:301080)是成立于2010年的跨国生物科技公司,是为全球生物医药、健康产业领域提供关键生物试剂产品及解决方案的行业平台型基石企业。2021年在创业板上市。百普赛斯集团业务遍布全球,横跨亚洲、北美洲、欧洲,在中国、美国、瑞士等12个城市设有办公室、研发中心及生产基地。目前累计服务客户超6000家,与全球Top 20医药企业均建立了长期、稳定的合作伙伴关系。集团旗下拥有品牌ACROBiosystems百普赛斯、bioSeedin柏思荟、Condense Capital垦拓资本和ACRODiagnostics百斯医学等。