Frizzled-4产品信息
英文名称:Frizzled-4
中文名称:卷曲蛋白-4
靶点别称:FZD4,Frizzled-4,CD344
物种:Human
标签:Fc Tag
属性:Protein
标记:Unconjugated
表达区间及表达系统(Source)
Human Frizzled-4, Fc Tag (FZ4-H5250) is expressed from human 293 cells (HEK293). It contains AA Phe 37 - Glu 180 (Accession # AAI14528).
Predicted N-terminus: Phe 37
蛋白结构(Molecular Characterization)

This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 42.9 kDa. The protein migrates as 50-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
内毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
纯度(Purity)
>95% as determined by SDS-PAGE.
制剂(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.
Contact us for customized product form or formulation.
重构方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存储(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.

背景(Background)
Frizzled-4(FZD4)也被称为FzE4、CD344,属于G蛋白偶联受体Fz/Smo家族。大多数卷曲受体与β-连环蛋白规范信号通路偶联,导致凌乱蛋白的激活、GSK-3激酶的抑制、β-连环素的核积累和Wnt靶基因的激活。FZD4包含一个FZ(卷曲)结构域。FZD4可能参与组织形态发生和/或分化组织中极性信息的转导和细胞间传递。FZD4与MAGI3和去甲灵(NDP)相互作用。
关键字: Frizzled-4;FZD4蛋白;FZD4重组蛋白;ACRO;百普赛斯;
百普赛斯集团ACROBiosystems Group(股票代码:301080)是成立于2010年的跨国生物科技公司,是为全球生物医药、健康产业领域提供关键生物试剂产品及解决方案的行业平台型基石企业。2021年在创业板上市。百普赛斯集团业务遍布全球,横跨亚洲、北美洲、欧洲,在中国、美国、瑞士等12个城市设有办公室、研发中心及生产基地。目前累计服务客户超6000家,与全球Top 20医药企业均建立了长期、稳定的合作伙伴关系。集团旗下拥有品牌ACROBiosystems百普赛斯、bioSeedin柏思荟、Condense Capital垦拓资本和ACRODiagnostics百斯医学等。