The POU2F2 antibody targets the POU2F2 protein, also known as Oct-2. a member of the POU-domain transcription factor family. POU2F2 plays a critical role in regulating gene expression, particularly in B-cell development and immune response modulation. It binds to octamer motifs in DNA, facilitating the activation or repression of target genes involved in cell differentiation, proliferation, and apoptosis. Structurally, it contains a POU-specific domain and a POU homeodomain, enabling sequence-specific DNA interactions.
Research highlights its importance in B-cell-specific gene regulation, including immunoglobulin gene expression. Dysregulation of POU2F2 has been linked to certain cancers, autoimmune disorders, and neurological conditions, making it a focus for therapeutic and diagnostic studies. The antibody is widely used in techniques like Western blotting, immunohistochemistry, and chromatin immunoprecipitation (ChIP) to detect POU2F2 expression and localization in tissues or cell lines.
Available as monoclonal or polyclonal versions, POU2F2 antibodies are typically validated for specificity and sensitivity across species, including human, mouse, and rat. Commercial suppliers often provide datasheets detailing applications, dilution protocols, and storage conditions. Understanding POU2F2's role in cellular pathways continues to shed light on its interactions with co-regulators and its potential as a biomarker or drug target in disease contexts.