SPDEF抗体

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Human cerebella tissue, Human cerebrum tissue, Mouse brain tissue lysates, Primary antibody: P07534(SPDEF Antibody) at dilution 1/600, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 10 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P07534(SPDEF Antibody) at dilution 1/75. (Original magnification: ×200)    

  
  

The SAM-pointed domain-containing Ets transcription factor (SPDEF), also known as prostate-derived Ets factor, is a member of the Ets family of transcription regulators. It is primarily expressed in epithelial cells of the prostate, gastrointestinal tract, respiratory system, and secretory glands, playing a critical role in regulating gene networks involved in cellular differentiation, mucus production, and barrier function. SPDEF contains a conserved Ets DNA-binding domain and a SAM (sterile alpha motif) domain, enabling protein-protein interactions and transcriptional regulation.

SPDEF antibodies are immunological tools developed to detect and study the expression, localization, and function of this protein. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence. Research has linked SPDEF to both tumor-suppressive and oncogenic roles, depending on tissue context. For example, it acts as a tumor suppressor in prostate cancer by inhibiting invasion, but may promote tumor progression in colorectal or breast cancers. Its involvement in mucus hypersecretion also ties it to chronic respiratory diseases like asthma and COPD. SPDEF antibodies thus serve as essential reagents in exploring its dual roles in cancer biology, epithelial homeostasis, and inflammatory disorders. Validated antibodies are critical due to potential cross-reactivity with other Ets family proteins.