PGF抗体,Rabbit Polyclonal PGF Antibody
  • PGF抗体,Rabbit Polyclonal PGF Antibody
  • PGF抗体,Rabbit Polyclonal PGF Antibody
  • PGF抗体,Rabbit Polyclonal PGF Antibody

PGF抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-13
QQ交谈 微信洽谈

产品详情

中文名称:PGF抗体英文名称:Rabbit Polyclonal PGF Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 3599 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: PGF
2025-05-13 PGF抗体 Rabbit Polyclonal PGF Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 3599 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB1/500-1/2000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesPGFL; PIGF; PLGF; PlGF-2; D12S1900; SHGC-10760
WB Predicted band size25 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFusion protein of human PGF
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

  •  

     

       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human placenta tissue lysate, Primary antibody: P07549(PGF Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 40 seconds    


  •  

     

       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P07549(PGF Antibody) at dilution 1/55. (Original magnification: ×200)    


  •  

     

       The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P07549(PGF Antibody) at dilution 1/55. (Original magnification: ×200)    


           

参考文献

以下是3篇与胎盘生长因子(Placental Growth Factor, PlGF)抗体相关的代表性文献概览(注:作者和标题为模拟示例,实际文献需通过数据库检索获取):

---

1. **标题**:*Anti-PlGF therapy inhibits tumor angiogenesis and metastasis*

**作者**:Carmeliet P, et al.

**摘要**:该研究通过开发靶向PlGF的单克隆抗体,证明抑制PlGF可显著减少多种癌症模型中肿瘤血管生成和转移,且不影响正常血管生理功能,提示PlGF抗体在抗肿瘤治疗中的潜力。

2. **标题**:*Structural basis of PlGF/VEGFR-1 antibody neutralization*

**作者**:Fischer C, et al.

**摘要**:通过晶体结构解析,揭示了PlGF与其受体VEGFR-1的结合机制,并验证了特定抗体通过阻断PlGF-VEGFR-1相互作用抑制病理性血管生成,为抗体药物优化提供结构依据。

3. **标题**:*PlGF blockade ameliorates neovascular age-related macular degeneration*

**作者**:Van de Veire S, et al.

**摘要**:在实验性湿性AMD模型中,抗PlGF抗体有效减少脉络膜新生血管形成,降低血管渗漏,表明PlGF是治疗视网膜血管疾病的潜在靶点。

---

**检索建议**:

可通过PubMed/Google Scholar搜索关键词“PlGF antibody”、“anti-PlGF therapy”或结合具体疾病(如“cancer”“AMD”)查找最新文献。推荐关注高影响力期刊(如*Nature Medicine*、*Cell Research*)及领域内知名团队(如Peter Carmeliet、Patricia D’Amore等)。

       

背景信息

Placental Growth Factor (PGF), a member of the vascular endothelial growth factor (VEGF) family, is a glycoprotein primarily involved in angiogenesis and vascular remodeling. Initially identified for its role in placental development and pregnancy, PGF binds to VEGF receptor-1 (VEGFR-1) and neuropilin co-receptors, modulating endothelial cell proliferation, migration, and survival. Unlike VEGF-A, PGF exhibits limited mitogenic activity but plays a compensatory role in pathological angiogenesis when VEGF-A signaling is impaired. Its expression is upregulated in hypoxic or inflammatory conditions, contributing to diseases such as cancer, diabetic retinopathy, and preeclampsia.

PGF-targeting antibodies have emerged as therapeutic tools to inhibit pathological angiogenesis. By neutralizing PGF or blocking its interaction with receptors, these antibodies aim to suppress aberrant vascular growth without disrupting physiological VEGF-A functions, potentially reducing side effects like hypertension or impaired wound healing associated with broad VEGF inhibition. Preclinical studies highlight PGF antibodies' efficacy in tumor regression and retinopathy models, though clinical translation remains ongoing. Additionally, PGF is explored as a diagnostic biomarker; altered serum levels correlate with preeclampsia severity, aiding early detection. Challenges include optimizing selectivity and understanding context-dependent roles, as PGF may exhibit both pro- and anti-angiogenic effects in different tissues. Overall, PGF antibodies represent a promising, though complex, avenue for targeted anti-angiogenic therapies. (298 words)

       
关键字: PGF抗体;PGF;PGF Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
询盘

店内推荐

PGF抗体相关厂家报价

产品名称 价格   公司名称 报价日期
询价
VIP4年
武汉佰乐博生物技术有限公司
2026-01-16
¥1950
VIP4年
上海沪震实业有限公司
2026-01-16
¥1280
VIP1年
上海臻科生物科技有限公司
2026-01-16
¥1280
湖北艾普蒂生物工程有限公司
2025-06-04
内容声明:
以上所展示的信息由商家自行提供,内容的真实性、准确性和合法性由发布商家负责。 商家发布价格指该商品的参考价格,并非原价,该价格可能随着市场变化,或是由于您购买数量不同或所选规格不同而发生变化。最终成交价格,请咨询商家,以实际成交价格为准。请意识到互联网交易中的风险是客观存在的
主页 | 企业会员服务 | 广告业务 | 联系我们 | 旧版入口 | 中文MSDS | CAS Index | 常用化学品CAS列表 | 化工产品目录 | 新产品列表 |投诉中心
Copyright © 2008 ChemicalBook 京ICP备07040585号  京公海网安备110108000080号  All rights reserved.