The SYT4 antibody targets Synaptotagmin-4 (SYT4), a member of the synaptotagmin family of calcium-binding proteins involved in membrane trafficking and synaptic transmission. Primarily expressed in neuronal tissues, SYT4 is localized to synaptic vesicles and secretory granules, where it regulates exocytosis and intracellular signaling. Unlike other synaptotagmins, SYT4 lacks a strong calcium-binding motif, suggesting distinct regulatory roles in neuroendocrine cells or plasticity-related processes. Studies link SYT4 to neurodevelopmental disorders, neurodegenerative diseases, and certain cancers, highlighting its diverse physiological and pathological relevance.
SYT4 antibodies are essential tools for detecting SYT4 expression and distribution in research applications such as Western blotting, immunohistochemistry, and immunofluorescence. They help elucidate SYT4’s interaction networks, subcellular localization, and functional contributions to vesicle dynamics or calcium-triggered secretion. Commercial SYT4 antibodies are typically validated for specificity across human, mouse, and rat models. However, variability in antibody performance (e.g., cross-reactivity with other synaptotagmins) necessitates careful validation for experimental accuracy. Ongoing research using SYT4 antibodies continues to uncover its role in synaptic plasticity, hormone release, and disease mechanisms, making it a critical reagent in neuroscience and cell biology.