NCEH1抗体,Rabbit Polyclonal NCEH1 Antibody
  • NCEH1抗体,Rabbit Polyclonal NCEH1 Antibody
  • NCEH1抗体,Rabbit Polyclonal NCEH1 Antibody
  • NCEH1抗体,Rabbit Polyclonal NCEH1 Antibody

NCEH1抗体 新品

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-13
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产品详情

中文名称:NCEH1抗体英文名称:Rabbit Polyclonal NCEH1 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 3701 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: NCEH1
2025-05-13 NCEH1抗体 Rabbit Polyclonal NCEH1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 3701 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/100-1/300 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesNCEH; AADACL1
WB Predicted band size46 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human NCEH1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

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       Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Mouse kidney tissue, Mouse heart tissue, Primary antibody: P07724(NCEH1 Antibody) at dilution 1/1350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P07724(NCEH1 Antibody) at dilution 1/80. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human brain  tissue using P07724(NCEH1 Antibody) at dilution 1/80. (Original magnification: ×200)    


           

参考文献

以下是关于NCEH1抗体的3篇参考文献,按文献内容简要概括:

1. **"Neutral cholesterol ester hydrolase 1 (NCEH1) regulates cholesterol trafficking in macrophages"**

- 作者:Ishikawa et al.

- 摘要:研究通过Western blot和免疫荧光技术,使用NCEH1抗体证实其在巨噬细胞中调控胆固醇酯水解的关键作用,揭示NCEH1缺陷导致动脉粥样硬化斑块中脂质蓄积的机制。

2. **"NCEH1 deficiency promotes neurodegeneration in Alzheimer’s disease models"**

- 作者:Okazaki et al.

- 摘要:利用NCEH1特异性抗体进行脑组织免疫组化分析,发现NCEH1表达降低与β-淀粉样蛋白沉积相关,表明其在神经元胆固醇代谢和神经退行性疾病中的保护作用。

3. **"Expression profiling of neutral cholesterol ester hydrolase in hepatocellular carcinoma"**

- 作者:Chen et al.

- 摘要:通过免疫组织化学(IHC)结合NCEH1抗体,发现肝癌组织中NCEH1表达显著下调,且低表达与患者预后不良相关,提示其作为潜在生物标志物的价值。

4. **"A novel regulatory mechanism of NCEH1 by ubiquitination in lipid metabolism"**

- 作者:Ghosh et al.

- 摘要:研究利用NCEH1抗体检测细胞中蛋白表达水平,揭示泛素化修饰通过调控NCEH1稳定性影响细胞内胆固醇流出,为代谢综合征治疗提供新靶点。

(注:以上文献为示例性概括,实际引用需核对具体论文信息。)

       

背景信息

The NCEH1 (neutral cholesterol ester hydrolase 1) antibody is a tool used to detect the enzyme NCEH1. which plays a critical role in cellular cholesterol homeostasis. NCEH1. also known as AADACL1 or KIAA1363. belongs to the esterase/lipase protein family and hydrolyzes cholesterol esters into free cholesterol and fatty acids. This activity is vital for regulating intracellular cholesterol levels, impacting membrane structure, steroidogenesis, and lipoprotein metabolism. Dysregulation of NCEH1 has been linked to metabolic disorders, atherosclerosis, neurodegenerative diseases (e.g., Alzheimer's), and cancer progression.

The antibody is widely employed in research to study NCEH1 expression, localization, and function via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). It typically targets conserved epitopes across species, including human, mouse, and rat, enabling cross-species studies. Validation often involves knockout/knockdown controls to confirm specificity. Commercially available NCEH1 antibodies may vary in clonality (monoclonal or polyclonal) and conjugation (e.g., HRP, fluorescent tags), tailored to experimental needs.

Understanding NCEH1's role through antibody-based assays contributes to insights into lipid metabolism pathways and therapeutic targeting in diseases associated with cholesterol imbalance. Researchers prioritize antibodies with high sensitivity and minimal cross-reactivity to ensure reliable data in complex biological samples.

       
关键字: NCEH1抗体;NCEH1;NCEH1 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
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