The AKAP7 antibody is a crucial tool for studying the A-kinase anchoring protein 7 (AKAP7), a member of the AKAP family that compartmentalizes protein kinase A (PKA) and other signaling molecules to specific subcellular locations. AKAP7 exists in multiple splice variants (e.g., γ, β, α) with distinct tissue expression and localization patterns, such as the plasma membrane, nucleus, or cytoplasm. It plays roles in regulating cardiac contractility, hormone secretion, and cell cycle progression by anchoring PKA to coordinate cAMP-responsive signaling pathways.
AKAP7 antibodies are designed to detect specific isoforms or shared epitopes, enabling applications like Western blotting, immunohistochemistry, and immunofluorescence. These antibodies help researchers investigate AKAP7's expression levels, cellular distribution, and interactions with binding partners (e.g., PKA, phosphodiesterases) under physiological or pathological conditions. Studies using AKAP7 antibodies have linked its dysregulation to cardiovascular diseases, reproductive disorders, and cancer progression.
Validated for specificity and sensitivity, AKAP7 antibodies (often raised in rabbits or mice) are essential for elucidating cAMP-PKA signaling mechanisms and exploring therapeutic targets. Their utility spans basic research and potential clinical diagnostics, particularly in diseases involving disrupted compartmentalized signaling.