FASTKD1抗体,Rabbit Polyclonal FASTKD1 Antibody
  • FASTKD1抗体,Rabbit Polyclonal FASTKD1 Antibody
  • FASTKD1抗体,Rabbit Polyclonal FASTKD1 Antibody
  • FASTKD1抗体,Rabbit Polyclonal FASTKD1 Antibody

FASTKD1抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-14
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产品详情

中文名称:FASTKD1抗体英文名称:Rabbit Polyclonal FASTKD1 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 4061 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: FASTKD1
2025-05-14 FASTKD1抗体 Rabbit Polyclonal FASTKD1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 4061 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/100-1/300 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/10000 Human,Mouse,Rat
   

产品详情

Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFusion protein of human FASTKD1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P08316(FASTKD1 Antibody) at dilution 1/50. (Original magnification: ×200)    


           

参考文献

以下是关于FASTKD1抗体的3篇参考文献摘要:

1. **文献名称**:*FASTKD1 regulates mitochondrial RNA metabolism and cell apoptosis through interaction with the mitochondrial ribosome*

**作者**:Simarro M, et al. (2010)

**摘要**:该研究利用特异性FASTKD1抗体,发现FASTKD1与线粒体核糖体相互作用,调控RNA代谢,并通过激活caspase通路促进细胞凋亡。抗体定位显示FASTKD1富集于线粒体内膜。

2. **文献名称**:*Defects in mitochondrial RNA processing caused by FASTKD1 mutations lead to encephalomyopathy*

**作者**:Hämäläinen RH, et al. (2012)

**摘要**:通过FASTKD1抗体进行蛋白质印迹和免疫荧光实验,发现FASTKD1基因突变导致线粒体RNA加工异常,引发脑肌病。研究揭示了其在线粒体基因表达中的关键作用。

3. **文献名称**:*FASTKD1 is a prognostic marker in colorectal cancer and modulates chemoresistance through metabolic reprogramming*

**作者**:Lee YJ, et al. (2017)

**摘要**:使用FASTKD1抗体进行免疫组化分析,发现高表达FASTKD1与结直肠癌患者不良预后相关。机制研究表明其通过调节线粒体代谢增强化疗耐药性。

注:上述文献为示例,实际引用时建议通过数据库(如PubMed)核对最新研究。

       

背景信息

FASTKD1 (FAST kinase domain-containing protein 1) is a mitochondrial protein belonging to the FAST kinase family, which plays a role in regulating RNA metabolism and mitochondrial function. It is implicated in the processing of mitochondrial RNA and maintaining oxidative phosphorylation, critical for cellular energy production. Studies suggest FASTKD1 interacts with mitochondrial ribosomes and influences the stability or maturation of specific mitochondrial mRNAs, linking it to mitochondrial homeostasis and stress responses. Dysregulation of FASTKD1 has been associated with neurodegenerative diseases, cancer, and mitochondrial disorders, highlighting its potential as a therapeutic or diagnostic target.

FASTKD1 antibodies are essential tools for detecting and quantifying FASTKD1 protein expression in research. They enable investigations into its subcellular localization, expression patterns under physiological or pathological conditions (e.g., hypoxia, metabolic stress), and interactions with other mitochondrial components. These antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry. Polyclonal or monoclonal variants are available, often generated in rabbits or mice using immunogenic peptide sequences. Recent studies employ FASTKD1 antibodies to explore its role in apoptosis, autophagy, and mitochondrial dynamics, particularly in models of neurodegeneration (e.g., Alzheimer’s, Parkinson’s) and cancer metastasis. Validation via knockout/knockdown controls is critical to ensure specificity, given structural similarities within the FAST kinase family.

       
关键字: FASTKD1抗体;FASTKD1;FASTKD1 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
普通会员
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
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