MAGEA11抗体,Rabbit Polyclonal MAGEA11 Antibody
  • MAGEA11抗体,Rabbit Polyclonal MAGEA11 Antibody
  • MAGEA11抗体,Rabbit Polyclonal MAGEA11 Antibody
  • MAGEA11抗体,Rabbit Polyclonal MAGEA11 Antibody

MAGEA11抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-14
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产品详情

中文名称:MAGEA11抗体英文名称:Rabbit Polyclonal MAGEA11 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 4984 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: MAGEA11
2025-05-14 MAGEA11抗体 Rabbit Polyclonal MAGEA11 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 4984 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/20-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

产品详情

AliasesCT1.11; MAGE11; MAGE-11; MAGEA-11
WB Predicted band size48 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFusion protein of human MAGEA11
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-3: K562, 293T and A549 cell lysates, Primary antibody: P09660(MAGEA11 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P09660(MAGEA11 Antibody) at dilution 1/20. (Original magnification: ×200)    


           

参考文献

以下是关于MAGEA11抗体的3篇参考文献示例(注:文献为模拟示例,实际引用需查询数据库):

1. **"MAGEA11 as a novel biomarker in prostate cancer: antibody development and clinical validation"**

- **作者**: Zhang Y, et al.

- **摘要**: 研究报道了针对MAGEA11的单克隆抗体的开发,并通过免疫组化证实其在前列腺癌组织中的高特异性表达,提示其作为诊断标志物的潜力。

2. **"Targeting MAGEA11 with therapeutic antibodies enhances anti-tumor immunity in melanoma"**

- **作者**: Rodriguez AA, et al.

- **摘要**: 利用人源化抗体靶向MAGEA11抗原,在黑色素瘤模型中激活T细胞免疫应答,抑制肿瘤生长,为免疫治疗提供新策略。

3. **"Epitope mapping of MAGEA11 antigen for antibody-based cancer therapy"**

- **作者**: Kim H, Park JH

- **摘要**: 通过表位定位技术鉴定MAGEA11的关键抗原区域,并开发高亲和力抗体,为靶向治疗提供结构基础。

如需真实文献,建议通过PubMed或Google Scholar搜索关键词“MAGEA11 antibody”获取最新研究。

       

背景信息

The MAGE-A11 antibody is a crucial tool for studying the melanoma-associated antigen A11. a member of the MAGE (melanoma antigen gene) family. MAGE proteins are cancer-testis antigens, typically expressed in germ cells and placenta but silenced in most somatic tissues. Their re-emergence in cancers, including melanoma, lung, prostate, and ovarian tumors, links them to oncogenesis and makes them potential immunotherapy targets. MAGE-A11. specifically, is implicated in transcriptional regulation, cell cycle progression, and apoptosis evasion. It interacts with androgen receptors (AR), enhancing their transcriptional activity, which may drive prostate cancer progression and resistance to therapies.

Antibodies targeting MAGE-A11 enable researchers to detect its expression in tissues or cell lines via techniques like immunohistochemistry (IHC), Western blot, or immunofluorescence. These antibodies are vital for understanding MAGE-A11’s role in tumor biology, prognostic significance, and its utility as a diagnostic or therapeutic biomarker. However, developing specific MAGE-A11 antibodies is challenging due to high homology among MAGE family members. Validated antibodies are essential to avoid cross-reactivity and ensure accurate experimental outcomes. Recent studies also explore MAGE-A11’s potential in adoptive T-cell therapies or cancer vaccines, underscoring the antibody’s importance in both basic research and clinical applications.

       
关键字: MAGEA11抗体;MAGEA11;MAGEA11 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
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