POLR1C抗体

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P09667(POLR1C Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P09667(POLR1C Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The POLR1C antibody targets a subunit of RNA polymerase I and III, essential enzymes responsible for synthesizing ribosomal RNA (rRNA) and small RNAs, including tRNA and 5S rRNA. POLR1C (RNA Polymerase I and III Subunit C) is a shared component of both polymerase complexes, playing a critical role in ribosomal biogenesis and transcriptional regulation. Mutations in the POLR1C gene are linked to autosomal recessive disorders such as Treacher Collins syndrome (TCS) and hypomyelinating leukodystrophy with hypodontia (HVDRR), characterized by craniofacial abnormalities or neurological deficits.

POLR1C antibodies are widely used in research to study RNA polymerase assembly, subcellular localization, and functional interactions. They aid in elucidating molecular mechanisms underlying POLR1C-associated diseases, including dysregulation of ribosome synthesis and cellular stress responses. These antibodies are applied in techniques like Western blotting, immunofluorescence, and immunohistochemistry to detect POLR1C expression in tissues or cultured cells. Commercial POLR1C antibodies are typically validated for specificity using knockout controls or siRNA knockdown. Researchers also utilize them to explore therapeutic strategies, such as gene therapy or small-molecule interventions, for POLR1C-related disorders. As a tool, POLR1C antibodies bridge genetic findings to functional insights in developmental biology and rare disease research.