RBM12抗体

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P09965(RBM12 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

The RBM12 antibody is a tool used to detect the RNA-binding motif protein 12 (RBM12), a protein encoded by the *RBM12* gene in humans. RBM12 belongs to the RNA-binding protein family, characterized by the presence of RNA recognition motifs (RRMs) that facilitate interactions with RNA molecules. This protein is implicated in post-transcriptional regulation, including mRNA processing, splicing, and translation. Studies suggest its involvement in cellular processes such as cell cycle control, apoptosis, and stress responses, with emerging roles in cancer biology and neurological disorders. Dysregulation of RBM12 has been linked to hepatocellular carcinoma, breast cancer, and neurodegenerative conditions, highlighting its potential as a biomarker or therapeutic target.

RBM12 antibodies are typically polyclonal or monoclonal antibodies generated by immunizing hosts (e.g., rabbits or mice) with purified RBM12 protein fragments or synthetic peptides. These antibodies are validated for applications like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and co-immunoprecipitation (Co-IP). Specificity is confirmed using knockout cell lines or siRNA-mediated knockdown controls. Commercial RBM12 antibodies often target epitopes within conserved regions, such as the N-terminal or RRM domains. Researchers use these antibodies to explore RBM12's molecular interactions, subcellular localization (primarily nuclear), and regulatory mechanisms in disease models. Due to its association with splicing machinery and signaling pathways (e.g., Wnt/β-catenin), RBM12 remains a focus in studies of gene expression networks and RNA biology.