The UBTD2 (Ubiquitin Domain-Containing Protein 2) antibody is a tool used to study the UBTD2 protein, which plays roles in ubiquitination-related cellular processes. UBTD2 contains a conserved ubiquitin-associated (UBA) domain, enabling interaction with ubiquitin or polyubiquitin chains, though its exact molecular functions remain under investigation. It is implicated in regulating protein degradation pathways, potentially influencing autophagy and proteasomal activity. Studies suggest UBTD2 may act as a scaffold or modulator in ubiquitin signaling, affecting cell cycle progression, stress responses, and apoptosis. Dysregulation of UBTD2 has been linked to cancers, neurodegenerative diseases, and metabolic disorders, highlighting its biomedical relevance. The UBTD2 antibody, typically developed in rabbit or mouse hosts, facilitates detection and localization of endogenous UBTD2 via techniques like Western blotting, immunofluorescence, or immunoprecipitation. Researchers use it to explore UBTD2 expression patterns, post-translational modifications, and interactions with binding partners. Its validation often includes knockout/knockdown controls to confirm specificity. Current research focuses on clarifying UBTD2's role in ubiquitin homeostasis and its potential as a therapeutic target in diseases involving proteostasis imbalance.