CHRDL1抗体,Rabbit Polyclonal CHRDL1 Antibody
  • CHRDL1抗体,Rabbit Polyclonal CHRDL1 Antibody
  • CHRDL1抗体,Rabbit Polyclonal CHRDL1 Antibody
  • CHRDL1抗体,Rabbit Polyclonal CHRDL1 Antibody

CHRDL1抗体 新品

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-15
QQ交谈 微信洽谈

产品详情

中文名称:CHRDL1抗体英文名称:Rabbit Polyclonal CHRDL1 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 6610 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: CHRDL1
2025-05-15 CHRDL1抗体 Rabbit Polyclonal CHRDL1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 6610 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/1000-1/2000 Human,Mouse,Rat
   

产品详情

AliasesCHL; MGC1; MGCN; VOPT; NRLN1; dA141H5.1
WB Predicted band size51 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human CHRDL1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: 293T cells, Human normal kidney tissue, Primary antibody: P12370(CHRDL1 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes    


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       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P12370(CHRDL1 Antibody) at dilution 1/35. (Original magnification: ×200)    


           

参考文献

以下是3篇涉及CHRDL1抗体的代表性文献及其摘要概括:

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1. **文献名称**: "CHRDL1 antagonizes BMP signaling in glioblastoma"

**作者**: Roth et al. (2016)

**摘要**: 研究报道CHRDL1在胶质母细胞瘤中通过分泌性蛋白形式抑制BMP4信号通路,利用特异性抗体证实其高表达与肿瘤细胞侵袭性降低相关,提示其作为潜在治疗靶点。

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2. **文献名称**: "Monoclonal antibody targeting CHRDL1 promotes axon regeneration"

**作者**: Zhang et al. (2020)

**摘要**: 开发了一种靶向CHRDL1的单克隆抗体,实验显示其能阻断CHRDL1与BMP受体的结合,在脊髓损伤模型中促进神经元轴突再生,验证了抗体在神经修复中的治疗潜力。

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3. **文献名称**: "CHRDL1 as a biomarker in breast cancer: Antibody-based detection"

**作者**: Lee et al. (2019)

**摘要**: 通过免疫组化和Western blot分析,利用CHRDL1抗体发现其在乳腺癌组织中表达下调,与BMP信号异常激活及患者预后不良相关,提出其作为诊断标志物的可能性。

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**备注**:若需获取完整文献,建议通过PubMed或Google Scholar以关键词“CHRDL1 antibody” + “BMP”/“cancer”/“therapeutic”进一步筛选近5年研究。部分研究可能侧重基因功能而非抗体开发,需结合摘要判断相关性。

       

背景信息

The CHRDL1 (Chordin-like 1) antibody is a tool used to detect and study the CHRDL1 protein, a secreted glycoprotein belonging to the Chordin family. CHRDL1 functions as an antagonist of bone morphogenetic proteins (BMPs), particularly BMP4. by binding to them and preventing interactions with their receptors. This modulation of BMP signaling is critical in developmental processes, including neurogenesis, osteogenesis, and ocular development. In the eye, CHRDL1 is highly expressed in the retina and regulates aqueous humor dynamics, linking it to glaucoma pathogenesis. Dysregulation of CHRDL1 has also been implicated in cancer, where it may act as a tumor suppressor by inhibiting BMP-driven cell proliferation and metastasis.

CHRDL1 antibodies are widely used in research applications such as Western blotting, immunohistochemistry, and ELISA to quantify protein expression, map tissue distribution, or assess functional interactions in developmental and disease models. Structurally, CHRDL1 contains conserved cysteine-rich domains essential for BMP binding, and specific antibodies often target these epitopes. Recent studies highlight its potential as a biomarker in diseases like glioblastoma and age-related macular degeneration. Research using CHRDL1 antibodies continues to explore its therapeutic relevance, particularly in conditions involving BMP pathway dysregulation.

       
关键字: CHRDL1抗体;CHRDL1;CHRDL1 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
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