MUC7抗体

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P12455(MUC7 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

MUC7. a member of the mucin family, is a low-molecular-weight, secreted glycoprotein predominantly expressed in salivary glands and mucosal surfaces of the respiratory tract. It plays critical roles in lubrication, microbial defense, and maintaining mucosal barrier integrity by forming a protective gel-like layer. The MUC7 protein contains tandem repeats rich in serine and threonine residues, which undergo extensive O-glycosylation, contributing to its structural and functional diversity.

Antibodies targeting MUC7 are valuable tools for studying its expression, localization, and interactions in physiological and pathological contexts. They are widely used in immunohistochemistry, ELISA, and Western blotting to investigate MUC7's involvement in diseases such as chronic obstructive pulmonary disease (COPD), asthma, oral infections, and cancers (e.g., salivary gland tumors). Research suggests altered MUC7 expression or glycosylation patterns may correlate with disease progression, microbial adhesion, or immune evasion.

Additionally, MUC7 antibodies hold diagnostic potential, as salivary MUC7 levels are explored as biomarkers for oral and systemic conditions. Therapeutic applications, though nascent, include targeting MUC7-pathogen interactions to prevent infections. Challenges remain in ensuring antibody specificity due to MUC7's glycosylation variability and homology with other mucins. Ongoing studies aim to refine antibody-based assays and explore clinical relevance in personalized medicine.