ALKBH8抗体,Rabbit Polyclonal ALKBH8 Antibody
  • ALKBH8抗体,Rabbit Polyclonal ALKBH8 Antibody
  • ALKBH8抗体,Rabbit Polyclonal ALKBH8 Antibody
  • ALKBH8抗体,Rabbit Polyclonal ALKBH8 Antibody

ALKBH8抗体—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-16
QQ交谈 微信洽谈

产品详情

中文名称:ALKBH8抗体英文名称:Rabbit Polyclonal ALKBH8 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 2177 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: ALKBH8
2025-05-16 ALKBH8抗体 Rabbit Polyclonal ALKBH8 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 2177 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesABH8; TRM9; TRMT9
WB Predicted band size75 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFull length fusion protein
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

  •  

     

       Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: A549 and Jurkat cell lysates, Primary antibody: P02220(ALKBH8 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 seconds    


  •  

     

       The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P02220(ALKBH8 Antibody) at dilution 1/25. (Original magnification: ×200)    


  •  

     

       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P02220(ALKBH8 Antibody) at dilution 1/25. (Original magnification: ×200)    


           

参考文献

以下是3篇关于ALKBH8抗体的参考文献及其摘要概括:

1. **"ALKBH8 regulates bladder cancer proliferation and prognosis through TKT-mediated glycolysis"**

- Fu, D., et al. (2018)

- 摘要:该研究利用ALKBH8抗体进行免疫组化分析,发现ALKBH8在膀胱癌组织中高表达,且与患者预后不良相关。实验表明ALKBH8通过调控转酮醇酶(TKT)促进糖酵解,进而驱动肿瘤增殖。

2. **"The AlkB family RNA demethylase ALKBH8 is required for late embryonic stem cell self-renewal"**

- Duncan, T., et al. (2016)

- 摘要:通过Western blot和免疫荧光(使用ALKBH8抗体),作者发现ALKBH8在维持胚胎干细胞多能性中起关键作用。ALKBH8缺失导致tRNA修饰异常,影响翻译效率和干细胞自我更新能力。

3. **"ALKBH8-mediated tRNA modification controls the translation of cancer-related proteins"**

- Ueda, Y., et al. (2020)

- 摘要:研究使用ALKBH8抗体进行免疫沉淀,揭示ALKBH8通过催化tRNA的mcm⁵U修饰,选择性调控促癌蛋白的翻译,为癌症治疗提供潜在靶点。

4. **"Structural basis of ALKBH8-mediated tRNA hypermodification"**

- Nakano, S., et al. (2019)

- 摘要:通过ALKBH8抗体纯化蛋白并解析其晶体结构,阐明ALKBH8与tRNA结合的分子机制,为理解其催化tRNA修饰的生化途径提供结构依据。

注:以上文献信息为示例性概括,具体内容需以实际发表的论文为准。

       

背景信息

The ALKBH8 antibody is a crucial tool for studying the AlkB homolog 8 protein, a member of the AlkB family of dioxygenases involved in RNA and DNA repair. ALKBH8 specifically catalyzes the post-transcriptional modification of transfer RNA (tRNA) by mediating the methylation of specific nucleotides, such as wybutosine, which stabilizes codon-anticodon interactions during translation. This enzyme plays a role in maintaining translational fidelity and cellular stress responses. The ALKBH8 antibody is widely used in research to detect and quantify ALKBH8 expression in various biological samples via techniques like Western blotting, immunohistochemistry, and immunofluorescence. It helps investigate ALKBH8's involvement in diseases, including cancer, where dysregulation of tRNA modifications may promote tumor progression. Additionally, the antibody aids in exploring ALKBH8's interaction with other proteins or nucleic acids through co-immunoprecipitation assays. Validated for specificity in multiple species (e.g., human, mouse), it is essential for functional studies, such as assessing ALKBH8 knockdown or overexpression effects on cellular processes. Research using this antibody has also linked ALKBH8 to neurological disorders and metabolic pathways, highlighting its broader biological significance. Overall, the ALKBH8 antibody is pivotal for advancing understanding of epitranscriptomic regulation and its implications in health and disease.
       
关键字: ALKBH8抗体;ALKBH8;ALKBH8 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业,
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
询盘

ALKBH8抗体—艾普蒂相关厂家报价

产品名称 价格   公司名称 报价日期
¥1600.00
VIP10年
北京索莱宝科技有限公司
2025-11-14
¥1800
VIP1年
费雪(杭州)医学研究有限公司
2025-11-03
询价
VIP3年
维百奥(北京)生物科技有限公司
2025-10-27
¥1280
湖北艾普蒂生物工程有限公司
2025-06-04
内容声明:
以上所展示的信息由商家自行提供,内容的真实性、准确性和合法性由发布商家负责。 商家发布价格指该商品的参考价格,并非原价,该价格可能随着市场变化,或是由于您购买数量不同或所选规格不同而发生变化。最终成交价格,请咨询商家,以实际成交价格为准。请意识到互联网交易中的风险是客观存在的
主页 | 企业会员服务 | 广告业务 | 联系我们 | 旧版入口 | 中文MSDS | CAS Index | 常用化学品CAS列表 | 化工产品目录 | 新产品列表 |投诉中心
Copyright © 2008 ChemicalBook 京ICP备07040585号  京公海网安备110108000080号  All rights reserved.