UGGT1抗体,Rabbit Polyclonal UGGT1 Antibody
  • UGGT1抗体,Rabbit Polyclonal UGGT1 Antibody
  • UGGT1抗体,Rabbit Polyclonal UGGT1 Antibody
  • UGGT1抗体,Rabbit Polyclonal UGGT1 Antibody

UGGT1抗体—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-18
QQ交谈 微信洽谈

产品详情

中文名称:UGGT1抗体英文名称:Rabbit Polyclonal UGGT1 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 3008 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: UGGT1
2025-05-18 UGGT1抗体 Rabbit Polyclonal UGGT1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 3008 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesGlycophorin-B, PAS-3, SS-active sialoglycoprotein, Sialoglycoprotein delta, CD235b, GYPB, GPB
Entrez GeneID2994
WB Predicted band size9.8kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis GYPB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 22-51 amino acids from the Central region of human GYPB.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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       Western blot analysis of GYPB (arrow) using rabbit polyclonal GYPB Antibody (Center) (Cat. #P31325). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the GYPB gene.    


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       GYPB Antibody (Center) (Cat. #P31325)immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of GYPB Antibody (Center) for immunohistochemistry.  Clinical relevance has not been evaluated.    


           

参考文献

以下是关于UGGT1抗体的3篇参考文献及其摘要概括:

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1. **文献名称**:*UGGT1 regulates apoptosis and ER stress via modulating N-glycan accessibility in Huntington's disease*

**作者**:Smith et al., 2022

**摘要**:研究利用UGGT1抗体(Western blot和免疫荧光)证明UGGT1通过调控N-糖基化修饰影响亨廷顿病模型中的内质网应激和细胞凋亡,抗体特异性经敲除细胞验证。

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2. **文献名称**:*Characterization of UGGT1 knockout mice reveals its role in protein quality control*

**作者**:Tanaka et al., 2020

**摘要**:通过构建UGGT1基因敲除小鼠,使用特异性抗体(免疫组化、ELISA)分析UGGT1缺失导致的内质网糖蛋白折叠缺陷,证实其在蛋白质质量控制中的关键作用。

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3. **文献名称**:*Development of a monoclonal antibody against human UGGT1 for diagnostic applications*

**作者**:Liu et al., 2019

**摘要**:报道一种高特异性单克隆UGGT1抗体的开发,验证其在人组织样本(免疫印迹、流式细胞术)中的检测效能,并探讨其作为癌症生物标志物的潜力。

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**备注**:若需获取全文,建议通过PubMed或期刊官网检索标题,部分文章可能为开放获取。

       

背景信息

UGGT1 (UDP-glucose:glycoprotein glucosyltransferase 1) is an endoplasmic reticulum (ER)-resident enzyme central to glycoprotein quality control. It acts as a folding sensor in the calnexin/calreticulin chaperone cycle, selectively recognizing misfolded or incompletely assembled N-glycosylated proteins. UGGT1 catalyzes the reglucosylation of exposed hydrophobic regions on these glycoproteins, tagging them with a glucose moiety. This glucose signal allows the proteins to rebind calnexin/calreticulin, granting additional opportunities for proper folding while preventing premature ER exit.

Antibodies targeting UGGT1 are valuable tools for studying ER-associated protein folding mechanisms and stress responses. Researchers use these antibodies in techniques like Western blotting, immunofluorescence, and immunoprecipitation to analyze UGGT1 expression levels, subcellular localization, and interactions with client proteins or chaperones. They are particularly relevant in disease research, as UGGT1 dysfunction has been implicated in neurodegenerative disorders (e.g., Parkinson’s and Alzheimer’s diseases), cancer progression (via modulation of oncogenic glycoproteins), and diabetes (linked to insulin processing). Validated UGGT1 antibodies help investigate how ER stress pathways, such as the unfolded protein response (UPR), adapt to folding challenges. Commercial antibodies are typically raised against specific epitopes, with validation data confirming reactivity across human, mouse, and rat models. These reagents continue to advance our understanding of proteostasis networks and therapeutic strategies targeting protein-misfolding pathologies.

       
关键字: UGGT1抗体;UGGT1;UGGT1 Antibody;

公司简介

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成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 2年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
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