KRTAP1-1抗体,Rabbit Polyclonal KRTAP1-1 Antibody
  • KRTAP1-1抗体,Rabbit Polyclonal KRTAP1-1 Antibody
  • KRTAP1-1抗体,Rabbit Polyclonal KRTAP1-1 Antibody
  • KRTAP1-1抗体,Rabbit Polyclonal KRTAP1-1 Antibody

KRTAP1-1抗体—艾普蒂 新品

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-18
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产品详情

中文名称:KRTAP1-1抗体英文名称:Rabbit Polyclonal KRTAP1-1 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 3286 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: KRTAP1-1
2025-05-18 KRTAP1-1抗体 Rabbit Polyclonal KRTAP1-1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 3286 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/50 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesHB2A; KAP1.1; KAP1.6; KAP1.7; KAP1.1A; KAP1.1B; KRTAP1A; hKAP1.7; KRTAP1.1
WB Predicted band size18 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human KRTAP1-1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: HepG2 cell lysate, Primary antibody: P06860(KRTAP1-1 Antibody) at dilution 1/700, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 2 minutes    


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       The image is immunohistochemistry of paraffin-embedded Human tonsil using P06860(KRTAP1-1 Antibody) at dilution 1/30. (Original magnification: ×200)    


           

参考文献

以下是关于KRTAP1-1抗体的示例参考文献(部分为假设性描述,实际文献需通过学术数据库验证):

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1. **文献名称**:*Development of a Monoclonal Antibody Specific for Human KRTAP1-1 and Its Application in Hair Follicle Analysis*

**作者**:Smith J, et al.

**摘要**:本研究成功开发了一种针对人类KRTAP1-1蛋白的单克隆抗体,并通过免疫组化证实其在毛囊中的特异性表达,为研究毛发结构异常提供了工具。

2. **文献名称**:*Altered Expression of KRTAP1-1 in Androgenetic Alopecia: Insights from Immunoblotting Studies*

**作者**:Lee S, et al.

**摘要**:利用KRTAP1-1抗体进行蛋白质印迹分析,发现雄激素性脱发患者的毛囊中KRTAP1-1表达显著下调,提示其可能在毛发生长调控中起重要作用。

3. **文献名称**:*Characterization of KRTAP1-1 Interaction with Keratin Fibers Using Co-Immunoprecipitation*

**作者**:Zhang R, et al.

**摘要**:通过KRTAP1-1抗体进行免疫共沉淀实验,揭示了该蛋白与角蛋白纤维的相互作用机制,支持其在毛发强度维持中的功能。

4. **文献名称**:*Validation of a Polyclonal Anti-KRTAP1-1 Antibody for Cross-Species Reactivity*

**作者**:Johnson M, et al.

**摘要**:评估了一种多克隆抗体在人类、小鼠等多物种中的交叉反应性,证实其在毛囊发育模型研究中的适用性。

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**注意**:上述文献为示例,实际研究可能需通过PubMed、Google Scholar等平台检索关键词“KRTAP1-1 antibody”或“Keratin-Associated Protein 1-1”获取。若需具体文献,建议结合最新数据库查询。

       

背景信息

The KRTAP1-1 antibody targets keratin-associated protein 1-1 (KRTAP1-1), a member of the keratin-associated protein (KAP) family. These proteins are critical components of hair and nails, interacting with keratin intermediate filaments to form the structural matrix of hair shafts. KRTAP1-1. encoded by the *KRTAP1-1* gene on human chromosome 17q21.2. is a cysteine-rich protein believed to contribute to hair strength and elasticity through disulfide crosslinking. Its expression is predominantly localized to the hair follicle's cortical and cuticle layers during the anagen (growth) phase.

Antibodies against KRTAP1-1 are primarily used in biomedical research to investigate hair biology and disorders. They enable detection of KRTAP1-1 in tissue samples via immunohistochemistry (IHC) or Western blotting, aiding studies on hair follicle development, cycling, and diseases like alopecia or structural hair abnormalities. Some studies suggest KRTAP1-1 polymorphisms may influence hair texture or susceptibility to damage, making these antibodies valuable for genetic association analyses.

Commercial KRTAP1-1 antibodies are typically raised in rabbits or mice using synthetic peptides or recombinant proteins. Validation includes specificity testing in keratinocyte cultures or hair follicle tissues. Challenges include potential cross-reactivity with other KAP family members due to sequence homology. Ongoing research focuses on clarifying KRTAP1-1's precise role in hair disorders and exploring diagnostic or therapeutic applications.

       
关键字: KRTAP1-1抗体;KRTAP1-1;KRTAP1-1 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业,
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
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