Mouse Monoclonal SOX11 Antibody,Mouse Monoclonal SOX11 Antibody
  • Mouse Monoclonal SOX11 Antibody,Mouse Monoclonal SOX11 Antibody
  • Mouse Monoclonal SOX11 Antibody,Mouse Monoclonal SOX11 Antibody
  • Mouse Monoclonal SOX11 Antibody,Mouse Monoclonal SOX11 Antibody

SOX11抗体;SOX11 Antibody—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-25
QQ交谈 微信洽谈

产品详情

中文名称:Mouse Monoclonal SOX11 Antibody英文名称:Mouse Monoclonal SOX11 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 1296 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Mouse
偶联物: 靶点: SOX11
2025-05-25 Mouse Monoclonal SOX11 Antibody Mouse Monoclonal SOX11 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 1296 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC咨询技术 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM1/200-1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesCSS9; MRD27
Entrez GeneID6664
clone1A6C10
WB Predicted band size46.7kDa
Host/IsotypeMouse IgG2b
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human SOX11 (AA: 1-250) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

+ +

  •  

     

       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng)    


  •  

     

       Flow cytometric analysis of Hela cells using SOX11 mouse mAb (green) and negative control (red).    


           

参考文献

以下是关于SOX11抗体的3篇代表性文献,按研究领域和内容整理:

---

1. **文献名称**:SOX11 expression in mantle cell lymphoma: Diagnostic and prognostic implications

**作者**:Ek S, Dictor M, Jerkeman M, et al.

**摘要**:该研究通过免疫组化分析SOX11在套细胞淋巴瘤(MCL)中的表达,证明其作为MCL诊断标志物的高特异性,并提示高SOX11水平与不良预后相关,支持其在临床病理学中的应用。

---

2. **文献名称**:SOX11 is a sensitive and specific antibody for detection of mantle cell lymphoma

**作者**:Barrans S, Crouch S, Care MA, et al.

**摘要**:研究比较了不同SOX11抗体的敏感性和特异性,发现特定克隆号抗体(如克隆MRQ-58)在MCL诊断中表现优异,强调了抗体选择对准确诊断的重要性。

---

3. **文献名称**:SOX11 promotes tumor angiogenesis through transcriptional regulation of PDGFA in neuroblastoma

**作者**:Shern JF, Chen L, Chmielecki J, et al.

**摘要**:该研究利用SOX11抗体探究其在神经母细胞瘤中的功能,发现SOX11通过调控PDGFA促进血管生成,为靶向治疗提供了潜在方向。

---

4. **文献名称**:SOX11 expression in ovarian carcinoma

**作者**:Köbel M, Bak J, Bertelsen BI, et al.

**摘要**:通过免疫组化分析卵巢癌组织,研究发现SOX11表达与肿瘤分化程度相关,高表达可能预示更差的生存结局,提示其作为预后标志物的潜力。

---

以上文献涵盖了SOX11抗体在淋巴瘤、神经肿瘤及实体瘤中的诊断、预后及机制研究,反映了其多领域应用价值。具体引用时建议通过PubMed或Web of Science核对原文信息。

       

背景信息

The SOX11 antibody is a valuable tool in biomedical research and diagnostics, targeting the SOX11 protein encoded by the *SOX11* gene, a member of the SOX (SRY-related HMG-box) transcription factor family. SOX11 plays critical roles in embryonic development, neurogenesis, and tissue regeneration, with emerging implications in cancer biology. It regulates gene expression by binding to DNA through its HMG domain, influencing cell differentiation, proliferation, and survival.

In oncology, SOX11 has gained attention as a biomarker for mantle cell lymphoma (MCL), where its overexpression aids in distinguishing MCL from other B-cell malignancies. Antibodies against SOX11 are widely used in immunohistochemistry (IHC) to detect nuclear SOX11 expression in tumor samples, enhancing diagnostic accuracy. Additionally, SOX11 is implicated in other cancers, including epithelial ovarian cancer and gliomas, where its expression correlates with tumor progression or prognosis.

SOX11 antibodies are typically developed using immunogenic peptides or recombinant proteins, validated for specificity in assays like Western blotting, IHC, and immunofluorescence. Challenges include cross-reactivity with homologous SOX proteins (e.g., SOX4. SOX12) due to conserved HMG domains, necessitating careful validation. Research applications extend to studying SOX11’s role in neural development, wound healing, and regenerative medicine.

Overall, SOX11 antibodies are pivotal in elucidating the protein’s dual roles in development and disease, offering insights into molecular pathways and potential therapeutic targets.

       
关键字: SOX11抗体;SOX11;SOX11 Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
询盘

SOX11抗体;SOX11 Antibody—艾普蒂相关厂家报价

产品名称 价格   公司名称 报价日期
询价
碧云天生物技术有限公司
2026-01-13
¥960.00
VIP10年
北京索莱宝科技有限公司
2026-01-16
¥4800
科博瑞(武汉)生物科技有限公司
2025-11-07
内容声明:
以上所展示的信息由商家自行提供,内容的真实性、准确性和合法性由发布商家负责。 商家发布价格指该商品的参考价格,并非原价,该价格可能随着市场变化,或是由于您购买数量不同或所选规格不同而发生变化。最终成交价格,请咨询商家,以实际成交价格为准。请意识到互联网交易中的风险是客观存在的
主页 | 企业会员服务 | 广告业务 | 联系我们 | 旧版入口 | 中文MSDS | CAS Index | 常用化学品CAS列表 | 化工产品目录 | 新产品列表 |投诉中心
Copyright © 2008 ChemicalBook 京ICP备07040585号  京公海网安备110108000080号  All rights reserved.