Mouse Monoclonal TSLPR Antibody,Mouse Monoclonal TSLPR Antibody
  • Mouse Monoclonal TSLPR Antibody,Mouse Monoclonal TSLPR Antibody
  • Mouse Monoclonal TSLPR Antibody,Mouse Monoclonal TSLPR Antibody
  • Mouse Monoclonal TSLPR Antibody,Mouse Monoclonal TSLPR Antibody

TSLPR抗体;TSLPR Antibody—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-25
QQ交谈 微信洽谈

产品详情

中文名称:Mouse Monoclonal TSLPR Antibody英文名称:Mouse Monoclonal TSLPR Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 1336 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Mouse
偶联物: 靶点: TSLPR
2025-05-25 Mouse Monoclonal TSLPR Antibody Mouse Monoclonal TSLPR Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 1336 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200-1/1000 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM1/200-1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesCRL2; TSLPR; CRLF2Y
Entrez GeneID64109
clone1E10D3
WB Predicted band size42kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human TSLPR (AA: extra(23-231)) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng)    


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       Flow cytometric analysis of THP-1 cells using TSLPR mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human bladder cancer tissues using TSLPR mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human rectal cancer tissues using TSLPR mouse mAb with DAB staining.    


           

参考文献

以下是关于TSLPR抗体的3篇代表性文献的简要总结(注:部分内容基于领域内典型研究方向模拟,具体文献需核实):

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1. **文献名称**:*Targeting TSLP/TSLPR in the Treatment of Asthma and Allergic Disease*

**作者**:Ziegler, S.F.; et al.

**摘要**:该研究探讨了TSLP-TSLPR信号通路在哮喘和过敏性疾病中的核心作用,开发了一种特异性抗TSLPR单克隆抗体,证明其可通过阻断TSLP与受体的结合,显著抑制Th2型炎症反应和气道高反应性,为靶向TSLPR的抗体疗法提供理论依据。

2. **文献名称**:*Monoclonal Antibody Against TSLPR Attenuates Experimental Atopic Dermatitis*

**作者**:Kim, B.S.; et al.

**摘要**:研究通过构建小鼠特应性皮炎模型,验证了抗TSLPR抗体通过抑制TSLP介导的树突状细胞活化及T细胞分化,有效减轻皮肤炎症和瘙痒症状,提示TSLPR抗体在治疗Th2主导的皮肤疾病中的潜力。

3. **文献名称**:*Structural Basis of TSLP Recognition by its Receptor TSLPR and Therapeutic Antibody Development*

**作者**:Liu, Y.; et al.

**摘要**:该研究解析了TSLP与TSLPR的复合物晶体结构,基于此设计了一种高亲和力人源化抗TSLPR抗体,体外实验显示其可阻断TSLP信号传导,并在灵长类模型中展现出良好的安全性和药代动力学特性,推动临床转化研究。

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**备注**:以上文献信息为模拟示例,实际研究中需通过PubMed或Web of Science等平台检索具体文献(关键词:TSLPR antibody, thymic stromal lymphopoietin receptor, monoclonal antibody)。真实文献可能涉及抗体功能验证、结构机制或临床试验等内容。

       

背景信息

TSLPR (thymic stromal lymphopoietin receptor) is a cytokine receptor subunit that pairs with IL-7Rα to form a functional receptor complex for thymic stromal lymphopoietin (TSLP), a key cytokine involved in type 2 immune responses. Discovered in the early 2000s, TSLPR belongs to the hematopoietin receptor family and is primarily expressed on dendritic cells, mast cells, and certain T-cell subsets. TSLP signaling through TSLPR/IL-7Rα activates downstream pathways like JAK-STAT, MAPK, and PI3K, driving allergic inflammation and promoting Th2 cytokine production.

Research has highlighted TSLPR's critical role in asthma, atopic dermatitis, and eosinophilic disorders. Its involvement in bridging innate and adaptive immunity made it a therapeutic target. TSLPR-blocking antibodies emerged as potential biologics to disrupt pathogenic TSLP signaling. Preclinical studies demonstrated efficacy in reducing airway inflammation and IgE production. In clinical trials, anti-TSLPR agents (e.g., tezepelumab) showed promise in moderate-to-severe asthma by attenuating exacerbations across multiple patient phenotypes, leading to FDA approval for tezepelumab in 2021. Ongoing research explores its utility in other TSLP-mediated conditions, including chronic urticaria and food allergies. However, long-term safety and broader immunomodulatory effects require further investigation.

       
关键字: TSLPR抗体;TSLPR;TSLPR Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
普通会员
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
询盘

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