Mouse Monoclonal CCL27 Antibody,Mouse Monoclonal CCL27 Antibody
  • Mouse Monoclonal CCL27 Antibody,Mouse Monoclonal CCL27 Antibody
  • Mouse Monoclonal CCL27 Antibody,Mouse Monoclonal CCL27 Antibody
  • Mouse Monoclonal CCL27 Antibody,Mouse Monoclonal CCL27 Antibody

CCL27抗体;CCL27 Antibody—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-25
QQ交谈 微信洽谈

产品详情

中文名称:Mouse Monoclonal CCL27 Antibody英文名称:Mouse Monoclonal CCL27 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 1354 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Mouse
偶联物: 靶点: CCL27
2025-05-25 Mouse Monoclonal CCL27 Antibody Mouse Monoclonal CCL27 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 1354 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC1/200 - 1/1000 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesALP; ILC; CTAK; CTACK; PESKY; ESKINE; SCYA27
Entrez GeneID10850
clone3B7A5
WB Predicted band size12.6kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human CCL27 (AA: 25-112) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Immunofluorescence analysis of Hela cells using CCL27 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)    


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       Flow cytometric analysis of HepG2 cells using CCL27 mouse mAb (green) and negative control (red).    


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       Flow cytometric analysis of Hela cells using CCL27 mouse mAb (green) and negative control (red).    


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       Flow cytometric analysis of A431 cells using CCL27 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human rectal cancer tissues using CCL27 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human stomach cancer tissues using CCL27 mouse mAb with DAB staining.    


           

参考文献

1. **"CCL27-CCR10 interactions regulate T cell-mediated skin inflammation"**

*Authors: Homey B, et al.*

摘要:该研究阐明了CCL27与其受体CCR10在皮肤炎症中的关键作用,利用特异性抗体阻断CCL27可减少T细胞向皮肤迁移,缓解小鼠皮炎模型症状。

2. **"Targeting CCL27 in cutaneous T-cell lymphoma: A therapeutic strategy"**

*Authors: Morales J, et al.*

摘要:研究发现CCL27抗体能抑制皮肤T细胞淋巴瘤(CTCL)细胞增殖并诱导凋亡,表明其作为CTCL靶向治疗的潜在价值。

3. **"CCL27 modulates dendritic cell function to promote cutaneous immunity"**

*Authors: Soler DC, et al.*

摘要:通过抗体中和实验证明,CCL27通过调控树突状细胞活性影响皮肤免疫应答,为银屑病等自身免疫性皮肤病提供机制解释。

4. **"Anti-CCL27 antibody attenuates allergic contact dermatitis in murine models"**

*Authors: Fujita H, et al.*

摘要:在小鼠接触性皮炎模型中,CCL27抗体显著减少嗜酸性粒细胞浸润和Th2细胞因子释放,提示其在过敏性疾病中的治疗潜力。

       

背景信息

CCL27. also known as cutaneous T-cell-attracting chemokine (CTACK), is a small chemokine belonging to the CC subfamily. It is primarily produced by keratinocytes in the skin and interacts with the CCR10 receptor, playing a critical role in immune surveillance and inflammatory responses. CCL27 facilitates the recruitment of CCR10-expressing T cells, particularly memory T lymphocytes, to cutaneous sites, making it essential for maintaining skin-specific immune homeostasis. Its expression is upregulated under inflammatory conditions, such as atopic dermatitis, psoriasis, and allergic contact dermatitis, implicating it in the pathogenesis of chronic skin disorders. Additionally, CCL27 has been linked to tumor immunity, as aberrant expression is observed in cutaneous T-cell lymphoma and melanoma.

CCL27 antibodies are immunological tools designed to detect or neutralize CCL27 protein activity. Polyclonal and monoclonal antibodies against CCL27 are widely used in research to study its biological functions, including ligand-receptor interactions, immune cell trafficking, and inflammatory signaling pathways. These antibodies enable techniques like ELISA, Western blotting, immunohistochemistry, and flow cytometry to quantify CCL27 levels in tissues or fluids, map its distribution, and assess its role in disease models. Neutralizing antibodies, in particular, are employed to block CCL27/CCR10 signaling in experimental settings, providing insights into therapeutic targeting for inflammatory skin diseases or cancer. The development and validation of CCL27 antibodies continue to support advances in dermatology, immunology, and oncology research.

       
关键字: CCL27抗体;CCL27;CCL27 Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
普通会员
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
询盘

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