The UQCRC1 antibody is a research tool designed to detect and study the Ubiquinol-Cytochrome c Reductase Core Protein 1 (UQCRC1), a critical subunit of mitochondrial Complex III (cytochrome bc1 complex) in the electron transport chain (ETC). UQCRC1 plays an essential role in oxidative phosphorylation by facilitating electron transfer from ubiquinol to cytochrome c, contributing to ATP synthesis. Dysregulation or mutations in UQCRC1 have been linked to mitochondrial disorders, metabolic diseases, and cancer, making it a target for investigating cellular energy metabolism and disease mechanisms.
UQCRC1 antibodies are commonly used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to assess protein expression, localization, and interactions. These antibodies help researchers explore UQCRC1's role in mitochondrial function, apoptosis, and reactive oxygen species (ROS) regulation. Commercial UQCRC1 antibodies are typically raised in rabbits or mice, available as monoclonal or polyclonal variants, with validation in specific applications and species (e.g., human, mouse, rat).
Recent studies highlight UQCRC1's potential involvement in cancer progression, neurodegeneration (e.g., Parkinson's disease), and metabolic syndromes, underscoring its biomedical relevance. However, users must verify antibody specificity due to potential cross-reactivity with homologous proteins. Proper controls and validation in experimental models remain crucial for reliable data interpretation.