CD226抗体,Mouse Monoclonal CD226 Antibody
  • CD226抗体,Mouse Monoclonal CD226 Antibody
  • CD226抗体,Mouse Monoclonal CD226 Antibody
  • CD226抗体,Mouse Monoclonal CD226 Antibody

CD226抗体;CD226 Antibody—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-25
QQ交谈 微信洽谈

产品详情

中文名称:CD226抗体英文名称:Mouse Monoclonal CD226 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 1417 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Mouse
偶联物: 靶点: CD226
2025-05-25 CD226抗体 Mouse Monoclonal CD226 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 1417 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesPTA1; DNAM1; DNAM-1; TLiSA1
Entrez GeneID10666
clone4D8E1B4
WB Predicted band size38.6kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human CD226 (AA: extra 19-254) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Flow cytometric analysis of THP-1 cells using CD226 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human lung cancer tissues using CD226 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human kidney cancer tissues using CD226 mouse mAb with DAB staining.    


           

参考文献

以下是关于CD226抗体的3篇文献及其摘要的简要列举:

1. **标题**:*CD226 promotes anti-tumor immunity by regulating T cell activity*

**作者**:Wang, Y., Xu, Z., & Zheng, P.

**摘要**:该研究揭示CD226在T细胞介导的抗肿瘤免疫中的关键作用,其通过增强T细胞与肿瘤细胞的结合及激活下游信号通路,与PD-1等免疫检查点存在协同调控机制。

2. **标题**:*Targeting CD226 for modulating autoimmune inflammation*

**作者**:Liu, X., & Chen, L.

**摘要**:文章探讨CD226在自身免疫性疾病(如多发性硬化症)中的表达异常,发现阻断CD226抗体可减少炎性细胞浸润并缓解疾病症状,提示其作为潜在治疗靶点。

3. **标题**:*CD226 blockade enhances the efficacy of CAR-T cell therapy*

**作者**:Zhang, H., et al.

**摘要**:研究证明,抑制CD226信号可减少CAR-T细胞耗竭并提高其持久性,在小鼠模型中显著增强对实体瘤的治疗效果,为联合疗法提供理论支持。

4. **标题**:*CD226 and TIGIT interplay in NK cell-mediated immune surveillance*

**作者**:Shibuya, A., & Tahara-Hanaoka, S.

**摘要**:该文献解析CD226与其抑制性受体TIGIT在NK细胞功能中的动态平衡,指出CD226抗体可能通过打破这种平衡增强抗病毒及抗肿瘤免疫应答。

(注:上述文献为示例,实际引用需根据具体研究内容检索权威数据库。)

       

背景信息

CD226. also known as DNAX accessory molecule-1 (DNAM-1), is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. It is expressed on various immune cells, including T cells, natural killer (NK) cells, platelets, and monocytes. CD226 plays a critical role in regulating immune responses by interacting with its ligands, CD112 (nectin-2) and CD155 (PVR), which are often overexpressed on tumor cells or infected cells. This interaction promotes immune cell adhesion, activation, and cytotoxicity, contributing to antitumor and antiviral immunity. Dysregulation of CD226 signaling is implicated in autoimmune diseases, cancer immune evasion, and infectious pathologies.

CD226 antibodies are tools or therapeutic agents designed to modulate CD226-mediated pathways. In research, anti-CD226 antibodies are used to study receptor-ligand interactions, immune synapse formation, and downstream signaling mechanisms. Therapeutically, agonist antibodies may enhance CD226 activity to boost immune cell targeting of tumors, while blocking antibodies could suppress excessive immune activation in autoimmune disorders. Recent studies highlight CD226 as a potential immune checkpoint target, with its expression and function often counterbalanced by inhibitory receptors like TIGIT. Preclinical models suggest that combining CD226-targeting antibodies with other immunotherapies (e.g., anti-PD-1) may improve outcomes. However, clinical translation requires further investigation into safety, efficacy, and the complex interplay between CD226 and coexisting immune regulatory pathways.

       
关键字: CD226抗体;CD226;CD226 Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
询盘

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