ALKBH1抗体;ALKBH1 Antibody—艾普蒂

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     Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Mouse pancreas tissue, Primary antibody: P07734(ALKBH1 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes    

  
  

ALKBH1 (AlkB homolog 1) is a member of the AlkB family of α-ketoglutarate-dependent dioxygenases, which are involved in nucleic acid repair and epigenetic regulation. It primarily functions as a demethylase targeting various DNA and RNA modifications, including N6-methyladenine (m6A) and N1-methyladenine (m1A) in DNA, as well as specific RNA modifications. ALKBH1 plays critical roles in transcriptional regulation, mitochondrial function, and genome stability, with implications in development, stem cell biology, and disease. Its enzymatic activity is closely associated with oxidative demethylation processes that influence chromatin structure and gene expression.

Antibodies against ALKBH1 are essential tools for studying its expression, localization, and molecular interactions. These antibodies are widely used in techniques such as Western blotting, immunoprecipitation (IP), and immunofluorescence (IF) to investigate ALKBH1's role in DNA/RNA repair, epigenetic modifications, and cellular stress responses. Specific monoclonal or polyclonal ALKBH1 antibodies are validated for species reactivity (e.g., human, mouse, rat) and application-specific compatibility. Researchers often employ knock-out cell lines or tissues to confirm antibody specificity. Dysregulation of ALKBH1 has been linked to cancer progression, neurological disorders, and mitochondrial diseases, making its antibodies valuable for exploring disease mechanisms and therapeutic targets. Recent studies also highlight its potential involvement in regulating tRNA modifications and translational efficiency, expanding its relevance in post-transcriptional gene regulation.