The oxysterol-binding protein-related protein 2 (OSBPL2), also known as ORP2. is a member of the OSBP-related protein family involved in lipid metabolism, intracellular trafficking, and cellular signaling. It binds oxysterols and cholesterol, playing roles in lipid homeostasis, membrane dynamics, and possibly vesicular transport. OSBPL2 contains pleckstrin homology (PH) and FFAT motifs, enabling interactions with phosphoinositides and endoplasmic reticulum membranes. Dysregulation of OSBPL2 has been implicated in cancer progression, neurological disorders, and atherosclerosis, though its precise mechanisms remain under investigation.
OSBPL2 antibodies are essential tools for detecting and quantifying OSBPL2 protein expression in research. They are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to study OSBPL2's subcellular localization, tissue distribution, and expression changes under pathological conditions. These antibodies aid in exploring OSBPL2's functional interactions with partners like INSIG1 or VAP proteins and its role in lipid-related pathways. Validation of antibody specificity is critical due to potential cross-reactivity with other OSBPL family members. Recent studies highlight OSBPL2's emerging importance in cancer cell proliferation and metastasis, making its antibodies valuable for both basic research and potential diagnostic applications.