RIOK1抗体;RIOK1 Antibody—艾普蒂

+ +

•  

   

     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P10196(RIOK1 Antibody) at dilution 1/80. (Original magnification: ×200)    

  
  

The RIOK1 antibody is a research tool designed to detect and study the RIO kinase 1 (RIOK1) protein, a member of the atypical kinase family involved in critical cellular processes. RIOK1. part of the evolutionarily conserved RIO kinase family (RIOK1. RIOK2. RIOK3), lacks canonical kinase activity but plays essential roles in ribosome biogenesis, cell cycle progression, and genome stability. It localizes predominantly in the cytoplasm and nucleolus, participating in 18S rRNA processing during ribosomal subunit maturation. Dysregulation of RIOK1 has been implicated in cancer, with overexpression observed in hepatocellular carcinoma, breast cancer, and glioblastoma, correlating with poor prognosis and tumor progression. Its interaction with pathways like mTOR and KRAS underscores its potential role in oncogenic signaling.

RIOK1 antibodies enable researchers to investigate protein expression, subcellular localization, and functional interactions through techniques like Western blotting, immunofluorescence, and immunoprecipitation. Recent studies highlight RIOK1's non-catalytic scaffolding functions in stress response and apoptosis regulation. The development of specific RIOK1 antibodies has advanced understanding of its structural features, including its unique kinase-like domain and ATP-binding motifs. These tools are crucial for exploring RIOK1's therapeutic potential as a biomarker or target in precision oncology, particularly in cancers driven by ribosomal dysfunction or aberrant cell cycle control.