ARHGEF11抗体,Rabbit Polyclonal ARHGEF11 Antibody
  • ARHGEF11抗体,Rabbit Polyclonal ARHGEF11 Antibody
  • ARHGEF11抗体,Rabbit Polyclonal ARHGEF11 Antibody
  • ARHGEF11抗体,Rabbit Polyclonal ARHGEF11 Antibody

ARHGEF11抗体;ARHGEF11 Antibody—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-26
QQ交谈 微信洽谈

产品详情

中文名称:ARHGEF11抗体英文名称:Rabbit Polyclonal ARHGEF11 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 6091 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: ARHGEF11
2025-05-26 ARHGEF11抗体 Rabbit Polyclonal ARHGEF11 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 6091 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

产品详情

AliasesGTRAP48; PDZ-RHOGEF
WB Predicted band size168 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human ARHGEF11
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Mouse brain tissue, Primary antibody: P11481(ARHGEF11 Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    


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       The image is immunohistochemistry of paraffin-embedded Human gasrtic cancer tissue using P11481(ARHGEF11 Antibody) at dilution 1/25. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P11481(ARHGEF11 Antibody) at dilution 1/25. (Original magnification: ×200)    


           

参考文献

以下是关于ARHGEF11抗体的3篇参考文献,按文献内容及抗体应用方向整理:

1. **文献名称**:*ARHGEF11 promotes proliferation and epithelial-mesenchymal transition in hepatocellular carcinoma through activation of β-catenin pathway*

**作者**:Li X, Zhang Y, Liu Q, et al.

**摘要**:该研究利用ARHGEF11抗体(Western blot和免疫组化)证实其在肝癌组织中高表达,并通过激活β-catenin信号通路促进肿瘤细胞增殖和转移。

2. **文献名称**:*ARHGEF11 interacts with Scribble to regulate cell polarity and migration in colorectal cancer cells*

**作者**:Wang H, Chen J, Deng Y, et al.

**摘要**:通过ARHGEF11抗体免疫共沉淀(Co-IP)实验,揭示了其与极性蛋白Scribble的相互作用,调控结直肠癌细胞极性和迁移,依赖RhoA/ROCK通路。

3. **文献名称**:*A novel role of ARHGEF11 in regulating glucose metabolism via mTORC1 signaling*

**作者**:Kim S, Park J, Lee K.

**摘要**:研究使用ARHGEF11抗体进行免疫荧光定位,发现其通过mTORC1通路影响胰岛β细胞的葡萄糖代谢功能,为糖尿病机制提供新靶点。

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**备注**:以上文献为模拟示例,实际研究中建议通过PubMed或Web of Science以“ARHGEF11 antibody”或“ARHGEF11 function”为关键词检索最新论文。若需具体文献,可补充研究背景进一步筛选。

       

背景信息

ARHGEF11 (Rho Guanine Nucleotide Exchange Factor 11), also known as PDZ-RhoGEF, is a member of the RhoGEF family that activates Rho GTPases by facilitating the exchange of GDP for GTP. It plays a critical role in regulating cytoskeletal reorganization, cell motility, and signaling pathways linked to G protein-coupled receptors (GPCRs). The protein contains a regulator of G-protein signaling (RGS) domain and a PDZ-binding motif, enabling interactions with various signaling molecules and scaffolding proteins. Dysregulation of ARHGEF11 has been implicated in pathological processes, including cancer metastasis, cardiovascular diseases, and neurological disorders.

ARHGEF11 antibodies are essential tools for studying its expression, localization, and function in cellular and disease models. These antibodies are commonly used in techniques such as Western blotting, immunofluorescence, and immunohistochemistry to detect ARHGEF11 in tissues or cultured cells. Researchers also employ them to investigate its role in RhoA-mediated signaling cascades and cross-talk with other pathways, such as Wnt or Hippo. Commercially available antibodies are typically raised against specific epitopes, often within conserved regions like the RGS or DH/PH domains. Validation includes testing for specificity via knockout cell lines or siRNA knockdown. Understanding ARHGEF11's mechanisms through antibody-based research may aid in developing therapeutic strategies targeting Rho GTPase pathways in diseases like hypertension or invasive cancers.

       
关键字: ARHGEF11抗体;ARHGEF11;ARHGEF11 Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
询盘

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