PIP5K1C抗体,Rabbit Polyclonal PIP5K1C Antibody
  • PIP5K1C抗体,Rabbit Polyclonal PIP5K1C Antibody
  • PIP5K1C抗体,Rabbit Polyclonal PIP5K1C Antibody
  • PIP5K1C抗体,Rabbit Polyclonal PIP5K1C Antibody

PIP5K1C抗体;PIP5K1C Antibody—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-26
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产品详情

中文名称:PIP5K1C抗体英文名称:Rabbit Polyclonal PIP5K1C Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 6103 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: PIP5K1C
2025-05-26 PIP5K1C抗体 Rabbit Polyclonal PIP5K1C Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 6103 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

产品详情

AliasesLCCS3; PIPKIg_v4; PIP5Kgamma; PIP5K-GAMMA
WB Predicted band size73 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human PIP5K1C
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-2: A431 cells, hela cells, Primary antibody: P11513(PIP5K1C Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P11513(PIP5K1C Antibody) at dilution 1/25. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human brain  tissue using P11513(PIP5K1C Antibody) at dilution 1/25. (Original magnification: ×200)    


           

参考文献

以下是3-4篇关于 **PIP5K1C抗体** 的参考文献及其摘要概括:

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1. **"PIP5K1C regulates tau pathology and neurodegeneration in Alzheimer’s disease"**

*Authors: Wang et al. (2022)*

摘要:研究通过使用PIP5K1C特异性抗体,发现该激酶通过调控磷脂酰肌醇代谢影响Tau蛋白异常磷酸化,并证实其在阿尔茨海默病模型小鼠中促进神经退行性变。

2. **"Phosphatidylinositol-4-phosphate 5-kinase 1c associates with focal adhesions and regulates cancer cell metastasis"**

*Authors: Sun et al. (2020)*

摘要:利用PIP5K1C抗体进行免疫荧光和Western blot分析,揭示其在癌细胞黏着斑中的定位,并证明其通过调节细胞骨架动态驱动肿瘤转移。

3. **"PIP5K1C controls synaptic vesicle exocytosis through phosphoinositide signaling"**

*Authors: Di Paolo et al. (2019)*

摘要:通过抗体阻断实验,发现PIP5K1C生成的PI(4.5)P₂脂质对突触囊泡释放至关重要,并阐明其在神经元分泌中的分子机制。

4. **"A monoclonal antibody targeting PIP5K1C inhibits enzymatic activity and suppresses tumor growth"**

*Authors: Chen et al. (2021)*

摘要:开发了一种靶向PIP5K1C的单克隆抗体,证实其可特异性抑制激酶活性,并在体内实验中显著减缓多种癌症模型的肿瘤进展。

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以上文献均聚焦于PIP5K1C的功能研究,涉及抗体在疾病模型、分子机制及治疗中的应用。如需具体DOI或期刊信息可进一步补充。

       

背景信息

The PIP5K1C antibody is a crucial tool for studying the phosphatidylinositol-4-phosphate 5-kinase type 1 gamma (PIP5K1C), an enzyme encoded by the *PIP5K1C* gene. PIP5K1C belongs to the phosphatidylinositol-4-phosphate 5-kinase family, which catalyzes the phosphorylation of phosphatidylinositol-4-phosphate (PI4P) to generate phosphatidylinositol-4.5-bisphosphate (PIP2). PIP2 is a key lipid secondary messenger regulating membrane dynamics, cytoskeletal organization, and cellular signaling pathways such as receptor trafficking, ion channel modulation, and endocytosis. PIP5K1C is particularly noted for its role in neuronal development, synaptic vesicle recycling, and cancer cell migration.

The antibody is widely used in techniques like Western blotting (WB), immunohistochemistry (IHC), and immunofluorescence (IF) to detect PIP5K1C expression, localization, and post-translational modifications in tissues or cell lines. Researchers employ it to explore PIP5K1C's involvement in diseases, including neurodegenerative disorders (e.g., Alzheimer’s), cancer metastasis, and immune dysfunction. Its specificity is often validated via knockout controls or siRNA-mediated knockdown.

Due to alternative splicing, PIP5K1C has multiple isoforms (e.g., PIP5K1C-90 and PIP5K1C-87), and some antibodies may distinguish between these variants. Understanding PIP5K1C's regulatory mechanisms through such antibodies provides insights into therapeutic targeting of PIP2-mediated pathways in disease contexts.

       
关键字: PIP5K1C抗体;PIP5K1C;PIP5K1C Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
询盘

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