PCARE抗体—艾普蒂 新品

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     IHC-P analysis of retina tissue by PCARE antibody (P15989) IHC-P was performed using sections of the formalin-fixed paraffin-embedded retina tissue;Result: Visual cone and visual rod layer are positively stained.    

  
  

PCARE (photoreceptor cilium actin regulator), also known as C2orf71. is a protein encoded by the PCARE gene located on chromosome 2p23.3. It gained attention due to its critical role in maintaining the structural and functional integrity of photoreceptor cells in the retina. Discovered through genetic studies on inherited retinal diseases (IRDs), PCARE is predominantly expressed in the connecting cilium of photoreceptors, a specialized structure essential for protein trafficking between the inner and outer segments of these light-sensing cells.

Mutations in the PCARE gene are linked to autosomal recessive retinitis pigmentosa (RP), a progressive degenerative disorder causing vision loss. Research suggests PCARE interacts with actin filaments and ciliary components, regulating cytoskeletal dynamics to ensure proper cilium stability and vesicular transport. Defects in PCARE disrupt these processes, leading to photoreceptor degeneration and impaired vision.

PCARE antibodies, developed for research and diagnostic purposes, enable the detection of PCARE protein expression and localization in retinal tissues. They serve as vital tools for studying disease mechanisms, validating gene therapy targets, and identifying pathogenic mutations in IRD patients. Recent studies also explore PCARE's potential involvement in ciliopathies beyond the retina, broadening its biomedical relevance. Despite its niche focus, PCARE research highlights the interplay between ciliary function and retinal health, offering insights into therapeutic strategies for hereditary blindness.