The BRK1 (Brick1) antibody is a valuable tool for studying the SCAR/WAVE regulatory complex (WRC), which plays a critical role in actin cytoskeleton remodeling. BRK1. a conserved subunit of the WRC, binds to other components like PIR121/Sra-1. Nap1. and HSPC300 to form a heteropentameric complex. This complex activates the Arp2/3-mediated actin nucleation process, essential for cell motility, membrane protrusion, and intracellular trafficking. Dysregulation of BRK1 or WRC is linked to developmental defects, immune disorders, and cancer metastasis. Researchers use BRK1 antibodies in techniques such as Western blotting, immunofluorescence, and immunoprecipitation to investigate its expression, localization, and interactions in cellular models. These studies help elucidate BRK1’s role in pathological conditions, including tumor invasion and neurological diseases. The antibody’s specificity and reliability make it crucial for advancing understanding of cytoskeletal dynamics and related therapeutic targets.