IPO8抗体,Rabbit Polyclonal IPO8 Antibody
  • IPO8抗体,Rabbit Polyclonal IPO8 Antibody
  • IPO8抗体,Rabbit Polyclonal IPO8 Antibody
  • IPO8抗体,Rabbit Polyclonal IPO8 Antibody

IPO8抗体;IPO8 Antibody—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-26
QQ交谈 微信洽谈

产品详情

中文名称:IPO8抗体英文名称:Rabbit Polyclonal IPO8 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 6306 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: IPO8
2025-05-26 IPO8抗体 Rabbit Polyclonal IPO8 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 6306 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/100-1/300 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesRANBP8
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human IPO8
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human gasrtic cancer tissue using P11858(IPO8 Antibody) at dilution 1/50. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P11858(IPO8 Antibody) at dilution 1/50. (Original magnification: ×200)    


           

参考文献

以下是关于IPO8抗体的3篇参考文献及其摘要:

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1. **"Importin-8 regulates transport of the TGF-β receptor and modulates TGF-β signaling"**

*Authors: Xu L, Alarcón C, Colozza G, et al.*

摘要:本研究揭示了IPO8作为TGF-β受体核转运的关键因子,通过特异性抗体阻断实验证明IPO8缺失会抑制TGF-β信号通路,影响细胞分化与肿瘤转移。

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2. **"The nuclear transport protein IPO8 is a driver of melanoma metastasis"**

*Authors: Winnepenninckx V, Debiec-Rychter M, Lazar V, et al.*

摘要:利用IPO8抗体进行免疫组化分析,发现IPO8在黑色素瘤中高表达,且其核转运功能促进肿瘤侵袭性,提示其作为潜在治疗靶点。

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3. **"Importin 8 mediates miRNA transport into the nucleus to promote gene silencing"**

*Authors: Wei Y, Li C, Zhang Q, et al.*

摘要:通过免疫沉淀结合IPO8抗体,研究证实IPO8协助特定miRNA进入细胞核,调控靶基因沉默,影响胚胎干细胞自我更新与分化。

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(注:若需更多文献,建议通过PubMed或Google Scholar以“IPO8 antibody”或“Importin 8 function”为关键词检索近年研究。)

       

背景信息

IPO8 (Importin-8) is a member of the importin-β family of nuclear transport receptors, which mediate nucleocytoplasmic trafficking of proteins and RNA molecules. Unlike classical importins, IPO8 functions independently of importin-α adapters, directly recognizing cargoes via specific nuclear localization signals (NLS). It plays a critical role in transporting ribosomal proteins, transcription factors, and other macromolecular complexes into the nucleus. Studies suggest IPO8 is involved in diverse cellular processes, including ribosome biogenesis, gene expression regulation, and viral replication, by ensuring proper localization of key regulatory factors.

The IPO8 antibody is a valuable tool for detecting endogenous IPO8 protein in applications such as Western blotting, immunofluorescence, and immunoprecipitation. Its specificity allows researchers to investigate IPO8 expression levels, subcellular localization, and interactions under physiological or pathological conditions. Recent research highlights IPO8's potential relevance in cancer, as dysregulated nuclear transport mechanisms are linked to tumor progression and drug resistance. Additionally, IPO8 has been implicated in antiviral responses, where it may influence host-pathogen interactions by mediating nuclear import of viral components.

Commercial IPO8 antibodies are typically raised against conserved epitopes, validated for cross-reactivity in human, mouse, and rat models. Proper controls, such as siRNA knockdowns, are recommended to confirm antibody specificity in experimental settings.

       
关键字: IPO8抗体;IPO8;IPO8 Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
询盘

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