KCNMB4抗体,Rabbit Polyclonal KCNMB4 Antibody
  • KCNMB4抗体,Rabbit Polyclonal KCNMB4 Antibody
  • KCNMB4抗体,Rabbit Polyclonal KCNMB4 Antibody
  • KCNMB4抗体,Rabbit Polyclonal KCNMB4 Antibody

KCNMB4抗体;KCNMB4 Antibody—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-26
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产品详情

中文名称:KCNMB4抗体英文名称:Rabbit Polyclonal KCNMB4 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 6320 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: KCNMB4
2025-05-26 KCNMB4抗体 Rabbit Polyclonal KCNMB4 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 6320 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/10000 Human,Mouse,Rat
   

产品详情

WB Predicted band size24 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human KCNMB4
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Mouse brain tissue, Primary antibody: P11878(KCNMB4 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P11878(KCNMB4 Antibody) at dilution 1/30. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human brain  tissue using P11878(KCNMB4 Antibody) at dilution 1/30. (Original magnification: ×200)    


           

参考文献

以下是关于KCNMB4抗体的3篇参考文献示例(注:内容为模拟概括,实际文献需通过学术数据库核实):

1. **"Differential expression of β-subunits of the large-conductance calcium-activated potassium channel in smooth muscle"**

- **作者**: Brenner, R., et al.

- **摘要**: 通过使用KCNMB4特异性抗体进行Western blot和免疫组化,研究发现KCNMB4在小鼠脑组织和血管平滑肌中高表达,提示其参与调节BK通道的生理功能多样性。

2. **"KCNMB4 regulates action potential firing in mouse hippocampal neurons"**

- **作者**: Behrens, C.J., et al.

- **摘要**: 利用KCNMB4抗体标记海马神经元,发现该亚基通过影响BK通道动力学调控神经元兴奋性,为癫痫相关研究提供潜在靶点。

3. **"Distinct cellular localization of KCNMB4 in human gliomas and its prognostic significance"**

- **作者**: Wang, Y., et al.

- **摘要**: 通过免疫组织化学(KCNMB4抗体)分析胶质瘤样本,发现KCNMB4蛋白表达水平与肿瘤分级和患者生存率显著相关,提示其作为生物标志物的可能性。

建议通过PubMed或Google Scholar以“KCNMB4 antibody”为关键词检索最新文献获取准确信息。

       

背景信息

The KCNMB4 antibody is a research tool designed to detect the KCNMB4 protein, a regulatory subunit of the large-conductance calcium-activated potassium (BK) channel. Encoded by the *KCNMB4* gene, this β-subunit modulates BK channel activity by influencing calcium sensitivity, voltage dependence, and channel kinetics. KCNMB4 is predominantly expressed in the brain, particularly in neurons, and plays a role in regulating neuronal excitability, neurotransmitter release, and vascular smooth muscle tone. Its dysfunction has been implicated in neurological disorders, hypertension, and cancer.

The antibody is commonly used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study KCNMB4 expression, localization, and interaction with BK channel α-subunits (e.g., KCNMA1). Researchers employ it to explore tissue-specific roles of KCNMB4. its regulation under physiological or pathological conditions, and its potential as a therapeutic target. Validation often includes testing in knockout models or siRNA-treated cells to confirm specificity. Challenges may arise from homology with other β-subunits (KCNMB1-3), necessitating careful experimental controls. Overall, the KCNMB4 antibody serves as a critical reagent for dissecting BK channel complexity and its impact on cellular physiology and disease mechanisms.

       
关键字: KCNMB4抗体;KCNMB4;KCNMB4 Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
询盘

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