MCC抗体;MCC Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P11932(MCC Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P11932(MCC Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

MCC (Merlin Coiled-Coil Protein) antibodies are primarily used to study the protein encoded by the *MCC* gene, initially identified as a candidate tumor suppressor in colorectal cancer. The *MCC* gene, located on chromosome 5q21. shares homology with the *APC* gene, another key tumor suppressor in colorectal carcinogenesis. MCC protein contains a coiled-coil domain, enabling interactions with cytoskeletal components and signaling molecules. While its precise molecular function remains under investigation, MCC is implicated in regulating cell adhesion, proliferation, and apoptosis, potentially through modulation of the Hippo-YAP signaling pathway or cytoskeletal dynamics.

In cancer research, MCC antibodies are critical tools for detecting protein expression levels via techniques like immunohistochemistry (IHC), Western blotting, or immunofluorescence. Reduced MCC expression has been observed in colorectal, gastric, and liver cancers, suggesting its role in tumor suppression. However, conflicting studies report MCC overexpression in certain malignancies, indicating context-dependent functions. Commercially available antibodies (e.g., polyclonal or monoclonal clones) vary in specificity, requiring validation for experimental models. Recent studies also explore MCC's involvement in non-cancer processes, such as neurodevelopment and immune regulation. Despite its discovery over three decades ago, MCC's full biological significance and therapeutic potential remain active areas of investigation.