RTN4R抗体,Rabbit Polyclonal RTN4R Antibody
  • RTN4R抗体,Rabbit Polyclonal RTN4R Antibody
  • RTN4R抗体,Rabbit Polyclonal RTN4R Antibody
  • RTN4R抗体,Rabbit Polyclonal RTN4R Antibody

RTN4R抗体;RTN4R Antibody—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-26
QQ交谈 微信洽谈

产品详情

中文名称:RTN4R抗体英文名称:Rabbit Polyclonal RTN4R Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 6392 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: RTN4R
2025-05-26 RTN4R抗体 Rabbit Polyclonal RTN4R Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 6392 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

产品详情

AliasesNGR; NOGOR
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human RTN4R
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P11990(RTN4R Antibody) at dilution 1/50. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P11990(RTN4R Antibody) at dilution 1/50. (Original magnification: ×200)    


           

参考文献

以下是关于RTN4R抗体的3篇参考文献示例(信息基于公开研究概括,非真实文献):

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1. **文献名称**: "Nogo Receptor (RTN4R) Expression in Multiple Sclerosis Lesions"

**作者**: Smith A, et al.

**摘要**: 本研究利用RTN4R特异性抗体进行免疫组化分析,发现多发性硬化症患者脑组织中RTN4R表达显著上调,且与髓鞘再生抑制相关,提示其在神经修复中的潜在调控作用。

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2. **文献名称**: "RTN4R Antibody-Based Blockade Enhances Axonal Regeneration in Spinal Cord Injury"

**作者**: Chen L, et al.

**摘要**: 通过RTN4R中和抗体阻断Nogo受体功能,实验显示脊髓损伤模型中小鼠轴突再生能力增强,证明RTN4R抗体在促进神经再生中的治疗潜力。

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3. **文献名称**: "Developmental Regulation of RTN4R in the Murine Brain"

**作者**: Johnson R, et al.

**摘要**: 采用RTN4R抗体进行Western blot和免疫荧光分析,揭示了该受体在小鼠大脑发育不同阶段的动态表达模式,提示其参与突触可塑性和神经环路形成。

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4. **文献名称**: "RTN4R Antibody Screening for Autoantibody Biomarkers in Neurological Disorders"

**作者**: Wang Y, et al.

**摘要**: 研究通过RTN4R抗体检测患者血清中的自身抗体,发现部分帕金森病患者存在RTN4R自身免疫反应,为疾病诊断提供了新生物标志物方向。

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注:以上为模拟内容,实际文献需通过PubMed/Google Scholar检索关键词如“RTN4R antibody”、“Nogo receptor antibody”获取。

       

背景信息

The RTN4R antibody targets the Reticulon 4 Receptor (RTN4R), also known as the Nogo Receptor, a glycoprotein predominantly expressed in the central nervous system (CNS). RTN4R plays a critical role in regulating axonal growth inhibition by binding to myelin-associated inhibitors like Nogo-A, MAG, and OMgp. These interactions activate intracellular signaling pathways, such as RhoA/ROCK, which suppress neuronal regeneration and plasticity. RTN4R is structurally characterized by leucine-rich repeats and belongs to the Nogo receptor family, which includes related proteins like LINGO-1 and NgR2. Its function is closely tied to limiting CNS repair post-injury, as it stabilizes neural circuits by restricting excessive axonal sprouting.

Antibodies against RTN4R are widely used in neuroscience research to study mechanisms of neural regeneration, synaptic plasticity, and CNS injury responses. By blocking RTN4R activity, these antibodies have been shown to enhance axonal regeneration in preclinical models of spinal cord injury and stroke. Additionally, RTN4R is implicated in neurological disorders such as Alzheimer's disease and multiple sclerosis, where its aberrant signaling may contribute to neurodegeneration. Research tools targeting RTN4R, including neutralizing antibodies, remain vital for exploring therapeutic strategies to overcome myelin-mediated inhibition and promote functional recovery in CNS pathologies.

       
关键字: RTN4R抗体;RTN4R;RTN4R Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
询盘

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