PLCL1抗体;PLCL1 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P12058(PLCL1 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

PLCL1 (Phospholipase C-like 1) is a protein encoded by the *PLCL1* gene, located on human chromosome 2p22.3. Structurally, it shares homology with phospholipase C (PLC) enzymes but lacks catalytic activity due to mutations in critical residues required for enzymatic function, classifying it as a "pseudoenzyme." PLCL1 is widely expressed in tissues, including the brain, immune cells, and skeletal muscle. Its biological role remains incompletely understood, though studies suggest involvement in cellular signaling, cytoskeletal organization, and regulation of calcium dynamics. It may act as a modulator or competitor in PLC-mediated pathways, influencing processes like cell proliferation and differentiation.

PLCL1 antibodies are essential tools for investigating its expression, localization, and interactions. They are utilized in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study tissue-specific distribution and disease associations. Dysregulation of PLCL1 has been implicated in various pathologies, including cancers (e.g., leukemia, colorectal cancer) and autoimmune disorders. For instance, reduced PLCL1 expression correlates with poor prognosis in certain malignancies, while autoantibodies against PLCL1 have been detected in autoimmune conditions like systemic sclerosis. However, research findings are sometimes inconsistent, potentially due to tissue-specific isoforms, post-translational modifications, or antibody specificity challenges. Validated PLCL1 antibodies are critical to clarify its role in health and disease.