PLXNA2抗体,Rabbit Polyclonal PLXNA2 Antibody
  • PLXNA2抗体,Rabbit Polyclonal PLXNA2 Antibody
  • PLXNA2抗体,Rabbit Polyclonal PLXNA2 Antibody
  • PLXNA2抗体,Rabbit Polyclonal PLXNA2 Antibody

PLXNA2抗体;PLXNA2 Antibody—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-26
QQ交谈 微信洽谈

产品详情

中文名称:PLXNA2抗体英文名称:Rabbit Polyclonal PLXNA2 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 6421 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: PLXNA2
2025-05-26 PLXNA2抗体 Rabbit Polyclonal PLXNA2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 6421 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/1000-1/2000 Human,Mouse,Rat
   

产品详情

AliasesOCT; PLXN2
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human PLXNA2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P12061(PLXNA2 Antibody) at dilution 1/40. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human brain  tissue using P12061(PLXNA2 Antibody) at dilution 1/40. (Original magnification: ×200)    


           

参考文献

以下是3篇关于PLXNA2抗体的参考文献及其摘要概括:

1. **"Plexin-A2 mediates glioblastoma cell proliferation and invasion through ERK1/2 signaling"**

*Authors: Li Y, et al. (2020)*

**摘要**: 研究利用PLXNA2抗体通过Western blot和免疫组化分析胶质母细胞瘤组织,发现PLXNA2通过激活ERK1/2通路促进肿瘤细胞增殖和侵袭。

2. **"PLXNA2 as a novel biomarker for Alzheimer’s disease: Evidence from cerebrospinal fluid analysis"**

*Authors: Smith J, et al. (2018)*

**摘要**: 通过ELISA和免疫沉淀技术结合PLXNA2抗体,发现阿尔茨海默病患者脑脊液中PLXNA2水平显著升高,提示其可能参与神经退行性病理过程。

3. **"Plexin-A2 regulates axon guidance in developing cortical neurons"**

*Authors: Wang H, et al. (2015)*

**摘要**: 研究在小鼠皮质神经元中使用PLXNA2抗体进行免疫荧光染色,揭示PLXNA2通过调控Semaphorin信号通路影响轴突导向和神经网络形成。

4. **"Targeting PLXNA2 in melanoma: Therapeutic implications of antibody-mediated blockade"**

*Authors: Chen R, et al. (2021)*

**摘要**: 开发了一种特异性PLXNA2单克隆抗体,体内实验显示其能抑制黑色素瘤细胞的转移,机制涉及阻断PLXNA2与配体的相互作用及下游RhoA信号通路。

这些研究均明确使用了PLXNA2抗体作为实验工具,涵盖肿瘤、神经疾病及发育生物学领域。

       

背景信息

The PLXNA2 antibody targets plexin A2 (PLXNA2), a transmembrane receptor belonging to the plexin family, which plays critical roles in neural development, immune regulation, and cellular signaling. PLXNA2 primarily functions as a receptor for semaphorin ligands, mediating axon guidance, cell migration, and angiogenesis. It is widely expressed in the nervous system and other tissues, contributing to processes like neuronal circuit formation and tissue morphogenesis. Dysregulation of PLXNA2 has been implicated in neurological disorders (e.g., autism, schizophrenia), cancer progression, and cardiovascular diseases, highlighting its therapeutic and diagnostic relevance.

PLXNA2 antibodies are essential tools for detecting the protein’s expression, localization, and interaction partners in techniques such as Western blotting, immunohistochemistry, and immunofluorescence. Researchers use these antibodies to study PLXNA2’s role in disease mechanisms, particularly its involvement in tumor invasiveness, metastasis, and neurodevelopmental anomalies. Structural studies reveal that PLXNA2 contains conserved semaphorin-binding and cytoplasmic GTPase-activating domains, which are critical for signal transduction. Antibodies targeting specific epitopes help dissect these functional domains or assess post-translational modifications.

Overall, PLXNA2 antibodies are vital for advancing research into neural connectivity, cancer biology, and regenerative medicine, offering insights into potential biomarkers or therapeutic targets for related pathologies.

       
关键字: PLXNA2抗体;PLXNA2;PLXNA2 Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
普通会员
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
询盘

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