SPATA5L1抗体;SPATA5L1 Antibody—艾普蒂

+ +

•  

   

     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: A549 cells, A172 cells, Primary antibody: P12237(SPATA5L1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human brain tissue using P12237(SPATA5L1 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P12237(SPATA5L1 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The SPATA5L1 antibody is a tool used to study the SPATA5L1 protein, encoded by the SPATA5L1 gene (spermatogenesis-associated 5-like 1). This gene belongs to the SPATA5 family, which shares structural similarities with ATPase proteins but lacks conserved catalytic domains. SPATA5L1 is ubiquitously expressed, with higher levels in testes, brain, and kidneys. Its exact biological role remains unclear, though studies suggest involvement in mitochondrial function, cell cycle regulation, and spermatogenesis. Interactions with proteins linked to ciliopathies and neurodevelopmental disorders hint at potential roles in cellular trafficking or structural organization.

SPATA5L1 antibodies are primarily used in research to detect protein expression via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Commercial antibodies are typically raised in rabbits or mice, targeting specific epitopes within the N- or C-terminal regions. Validation data often include reactivity in human, mouse, or rat tissues. Interest in SPATA5L1 has grown due to its association with diseases: genomic deletions overlapping SPATA5L1 correlate with developmental delays, while dysregulation has been observed in cancers. However, functional studies remain limited, and antibody specificity challenges persist due to high homology with SPATA5 paralogs. Ongoing research aims to clarify its molecular mechanisms and therapeutic potential.