STARD4抗体,Rabbit Polyclonal STARD4 Antibody
  • STARD4抗体,Rabbit Polyclonal STARD4 Antibody
  • STARD4抗体,Rabbit Polyclonal STARD4 Antibody
  • STARD4抗体,Rabbit Polyclonal STARD4 Antibody

STARD4抗体;STARD4 Antibody—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-26
QQ交谈 微信洽谈

产品详情

中文名称:STARD4抗体英文名称:Rabbit Polyclonal STARD4 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 6535 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: STARD4
2025-05-26 STARD4抗体 Rabbit Polyclonal STARD4 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 6535 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

WB Predicted band size24 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human STARD4
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-5: HepG2 cell, Human liver tissue, Mouse liver tissue, Human fetal liver tissue, LO2 cell lysates, Primary antibody: P12247(STARD4 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 minute    


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       The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P12247(STARD4 Antibody) at dilution 1/50. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P12247(STARD4 Antibody) at dilution 1/50. (Original magnification: ×200)    


           

参考文献

以下是关于STARD4抗体的3篇参考文献示例(内容为模拟概括,建议通过数据库核实原文):

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1. **文献名称**: *"STARD4 mediates macrophage cholesterol efflux and promotes reverse cholesterol transport"*

**作者**: Kanno K, et al.

**摘要**: 本研究利用STARD4特异性抗体,验证了该蛋白在巨噬细胞中的表达定位。实验表明,STARD4通过促进胆固醇从细胞内向HDL的转运,减少泡沫细胞形成,提示其在动脉粥样硬化中的潜在保护作用。

2. **文献名称**: *"Regulation of STARD4 expression in hepatic cells by LXR and SREBP pathways"*

**作者**: Rodriguez-Agudo D, et al.

**摘要**: 通过Western blot和免疫荧光(使用兔源STARD4多克隆抗体),发现肝细胞中STARD4的表达受LXR和SREBP转录因子双重调控,并参与肝细胞内胆固醇的储存与运输调控。

3. **文献名称**: *"Characterization of the STAR protein family: Focus on STARD4's role in cellular lipid homeostasis"*

**作者**: Soccio RE, et al.

**摘要**: 文章首次报道了针对STARD4蛋白的单克隆抗体制备,并通过免疫印迹验证其特异性。研究发现STARD4通过结合胆固醇并促进其在胞内运输,维持脂代谢稳态,与Ⅱ型糖尿病发病风险相关。

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**注意**:以上文献信息为示例性概括,实际文献需通过PubMed、Google Scholar等平台以“STARD4 antibody”或“STARD4 function”为关键词检索。若需具体抗体产品文献,可查询抗体生产商(如Abcam、CST)提供的引用列表。

       

背景信息

The STARD4 antibody is a research tool designed to detect and analyze the STARD4 (StAR-related lipid transfer domain-containing protein 4) protein, a member of the STARD family involved in intracellular cholesterol transport and lipid metabolism. STARD4 facilitates non-vesicular cholesterol movement between membranes, particularly in maintaining cellular cholesterol homeostasis by shuttling cholesterol from the plasma membrane to the endoplasmic reticulum. Its expression is regulated by sterol levels via SREBP (sterol regulatory element-binding protein) pathways, linking it to diseases like atherosclerosis, metabolic syndrome, and cancers where cholesterol dysregulation occurs.

Antibodies against STARD4 enable researchers to study its expression patterns, subcellular localization, and interactions in models of lipid-related disorders. For example, they are used in Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to assess STARD4 levels in tissues or cultured cells under varying sterol conditions. Commercially available STARD4 antibodies are typically raised in rabbits or mice using immunogenic peptide sequences unique to the protein. Validation often includes knockout cell lines or siRNA-mediated silencing to confirm specificity.

These tools have advanced understanding of STARD4's role in lipid signaling, cancer progression (e.g., hepatocellular carcinoma), and neurodegenerative diseases. However, challenges remain in standardizing antibody performance across experimental platforms. Ongoing research aims to clarify STARD4's mechanistic contributions to cellular cholesterol balance and its potential as a therapeutic target.

       
关键字: STARD4抗体;STARD4;STARD4 Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
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