CLDN15抗体;CLDN15 Antibody—艾普蒂 新品

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Human colon sigmoideum cancer tissue, Primary antibody: P12484(CLDN15 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds    

  
  

Claudin-15 (CLDN15) is a member of the claudin family, a group of transmembrane proteins critical for forming tight junctions that regulate paracellular transport and maintain cell polarity. CLDN15 is primarily expressed in epithelial tissues, notably the small intestine and kidneys, where it plays a key role in selective ion permeability. Structurally, it contains four transmembrane domains, two extracellular loops, and cytoplasmic N- and C-termini. The second extracellular loop determines its ion selectivity, enabling CLDN15 to form cation-selective channels that facilitate Na⁺ absorption and fluid homeostasis. Dysregulation of CLDN15 is linked to gastrointestinal disorders (e.g., diarrhea, malabsorption syndromes) and renal electrolyte imbalances.

CLDN15 antibodies are essential tools for studying its localization, expression, and functional roles in physiological and pathological contexts. They are used in techniques like immunohistochemistry, Western blotting, and flow cytometry. Research suggests therapeutic potential: blocking CLDN15 may mitigate hypersecretory diarrhea, while enhancing its function could address nutrient absorption defects. Additionally, CLDN15 is explored in cancer research due to claudins' roles in tumor progression and metastasis. Its overexpression in certain cancers positions it as a potential diagnostic marker or therapeutic target. CLDN15 antibodies thus hold promise for both basic research and clinical applications, bridging gaps in understanding epithelial barrier dynamics and disease mechanisms.