盐酸RGX-104|T5128|TargetMol

价格	￥343	￥496	￥993
包装	1mg	2mg	5mg

最小起订量	1mg
发货地	上海
更新日期	2025-11-17

QQ交谈微信洽谈

产品详情

中文名称:盐酸RGX-104	英文名称:RGX-104 hydrochloride
CAS:610318-03-1	品牌: TargetMol
产地: 美国	保存条件: keep away from direct sunlight,keep away from moisture,store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
纯度规格: 99.06%	产品类别: 抑制剂
货号: T5128

Product Introduction

Bioactivity

名称	RGX-104 hydrochloride
描述	RGX-104 hydrochloride (SB742881) is a liver X receptor (LXR) agonist with potential immunomodulating and antineoplastic activities. It modulates innate immunity via transcriptional activation of the ApoE gene.
细胞实验	Myeloid-derived suppressor cells were isolated as previously described from splenic tissue of tumor-bearing mice. One hundred thousand cells were plated in quadruplicates in poly-L-lysine coated plates. After 3 hours of treatment with 1uM RGX-104 or DMSO as vehicle, cells were fixed with 4% PFA for 15 minutes and wash 3 times with 1X PBS prior staining. Rabbit monoclonal anti-Ki67 antibody (1:400 dilution) was applied at 4C overnight. Cells were incubated with Alexa Fluor 488 secondary antibody (1:200 dilution) for one hour at room temperature, counterstained with DAPI (1:1000 dilution) and mounted with Prolong Gold. For the analysis of the percentage of Ki67 positive cells, five fields from each replicate were imaged at 20x magnification using Zeiss Axio Imager fluorescence microscope.
动物实验	For MDSC adoptive transfer experiments into tumor-bearing mice, 2 × 10^6 MDSCs were isolated as described above from C57BL/6 tumor-bearing mice and subsequently labeled with BD Horizon Violet (BV) Proliferation Dye and then adoptively transferred via retro-orbital injection into wild-type mice. Mice were then treated with RGX-104 (100 mg/kg/day) or control diet for 36 hours. Spleens of recipient mice were then harvested and processed for flow cytometry analysis as described above. For MDSC adoptive transfer experiments in to WT and ApoE?/? non-tumor bearing mice, 5 × 10^6 MDSCs were isolated as described above from tumor-bearing mice (either wild-type C57BL/6 or Apoe?/? mice) and subsequently labeled with BV cell tracker dye and then adoptively transferred via retro-orbital injection into either wild-type or Apoe?/? mice. Mice were then treated with GW3965 (100 mg/kg/day) or control diet for 48 hours. Spleens of recipient mice were then harvested and processed for flow cytometry analysis.
体内活性	通过口服给予动物RGX-104显著抑制了多种癌症类型的可触及肿瘤生长。在携带大型肿瘤的动物中，也观察到强烈的肿瘤生长抑制作用。与对照组相比，经过8天的治疗后，以RGX-104（100 mg/kg）处理的小鼠中，总CD45+淋巴细胞中凋亡性循环G-MDSCs显著增加。
存储条件	keep away from direct sunlight,keep away from moisture,store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	DMSO : 115 mg/mL (181.81 mM), Sonication is recommended.
关键字	SB-742881 \| SB 742881 \| RGX-104 Hydrochloride \| RGX104 hydrochloride \| RGX104 Hydrochloride \| RGX-104 \| RGX104 \| RGX 104 hydrochloride \| RGX 104 Hydrochloride \| RGX 104 \| LXR \| LiverXReceptor \| Liver X receptor \| Liver X Receptor \| Inhibitor \| inhibit
相关产品	SR9243 \| (20S)-Protopanaxatriol \| T0901317 \| GW6340 \| Rovazolac \| GSK2033 \| SR9238 \| RGX-104 \| LXR-623 \| GW3965 hydrochloride \| BE1218 \| GAC0003A4
相关库	抗癌活性化合物库 \| NO PAINS 化合物库 \| 血液病分子库 \| 核受体化合物库 \| 临床期小分子药物库 \| 口服活性化合物库 \| 抗代谢疾病化合物库 \| 抗癌临床化合物库 \| 抗癌药物库

关键字：盐酸RGX-104|||SB742881|||RGX-104 HCl|TargetMol

公司简介

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

成立日期	2013-04-18 （13年）	注册资本	566.265100万人民币
员工人数	100-500人	年营业额	￥ 1亿以上
主营行业	天然产物,生化试剂,分子生物学,分子砌块,生物技术服务	经营模式	贸易,工厂,试剂,定制,服务

TargetMol中国（陶术生物）

VIP 4年

公司成立：13年
注册资本：566.265100万人民币
企业类型：有限责任公司(自然人投资或控股)
主营产品：小分子抑制剂、药物筛选化合物库、药物筛选等
公司地址：静安区江场三路238号8楼

进入店铺

询盘

店内推荐

化合物 5-PT|Fr21317|TargetMol

￥1300

苯五甲酸|T18924|TargetMol

￥671

阿塞西普|T78302|TargetMol

￥11300

盐酸RGX-104|T5128|TargetMol相关厂家报价

产品名称	价格		公司名称	报价日期
TAL-104	￥5000	VIP1年	上海抚生实业有限公司	2026-01-14
艾沙康唑杂质104(氯盐	询价	VIP1年	湖北摩科生物科技有限公司	2026-01-14
MA-104 [MA 104; MA104]（罗猴胎肾细胞）	￥1500	VIP4年	上海沪震实业有限公司	2026-01-13
RGX-104 HCl	询价	VIP8年	台州市科瑞生物技术有限公司	2025-07-31
aladdin 阿拉丁 R414117 RGX-104 hydrochloride 610318-03-1 98%	￥3666.90	VIP2年	上海阿拉丁生化科技股份有限公司	2025-05-16

内容声明:
以上所展示的信息由商家自行提供，内容的真实性、准确性和合法性由发布商家负责。商家发布价格指该商品的参考价格，并非原价，该价格可能随着市场变化，或是由于您购买数量不同或所选规格不同而发生变化。最终成交价格，请咨询商家，以实际成交价格为准。请意识到互联网交易中的风险是客观存在的