GZMH抗体,Rabbit Polyclonal GZMH Antibody
  • GZMH抗体,Rabbit Polyclonal GZMH Antibody
  • GZMH抗体,Rabbit Polyclonal GZMH Antibody
  • GZMH抗体,Rabbit Polyclonal GZMH Antibody

GZMH抗体;GZMH Antibody—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-26
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产品详情

中文名称:GZMH抗体英文名称:Rabbit Polyclonal GZMH Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 6772 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: GZMH
2025-05-26 GZMH抗体 Rabbit Polyclonal GZMH Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 6772 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesCCP-X; CGL-2; CSP-C; CTLA1; CTSGL2
WB Predicted band size27 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human GZMH
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Hela and 231 cell lysates, Primary antibody: P12651(GZMH Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 minute    


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       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer using P12651(GZMH Antibody) at dilution 1/75. (Original magnification: ×200)    


           

参考文献

以下是3篇关于GZMH(颗粒酶H)抗体的参考文献,涵盖其功能研究和应用:

1. **文献名称**: *"Granzyme H serum levels are associated with CD8+ T cell immunity in patients with hepatocellular carcinoma"*

**作者**: Li, Y. et al.

**摘要**: 该研究通过开发特异性GZHM抗体,检测肝细胞癌患者血清中GZMH水平,发现其与CD8+ T细胞活性及患者预后显著相关,提示GZMH可能作为免疫治疗的潜在标志物。

2. **文献名称**: *"A novel monoclonal antibody against human granzyme H for functional characterization in cytotoxic lymphocyte-mediated apoptosis"*

**作者**: Müller, L. et al.

**摘要**: 研究团队报道了一种新型GZMH单克隆抗体的开发,验证了其在流式细胞术和Western blot中的特异性,并证明其能有效阻断颗粒酶H介导的靶细胞凋亡,为免疫机制研究提供工具。

3. **文献名称**: *"Differential expression of granzyme H in human lymphocyte subsets identifies unique functional roles in inflammation"*

**作者**: Wang, Q. et al.

**摘要**: 通过GZHM抗体的免疫组化分析,揭示了颗粒酶H在NK细胞和Th1细胞亚群中的差异性表达,并发现其在慢性炎症疾病中调控细胞因子分泌的功能。

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如需获取具体文献全文,建议通过PubMed或ResearchGate检索标题或作者。

       

背景信息

Granzyme H (GZMH) antibody is a tool used to detect and study the function of GZMH, a serine protease in the granzyme family. Granzymes are primarily expressed in cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells, where they contribute to immune defense by inducing apoptosis in virus-infected or tumorigenic cells. Unlike the well-characterized Granzyme B (GZMB), which cleaves caspases to trigger programmed cell death, GZMH exhibits distinct substrate specificity and enzymatic activity. It is thought to play a role in alternative cell death pathways or immune modulation, though its precise biological mechanisms remain less understood.

Research suggests GZMH may be involved in antiviral responses, particularly against herpesviruses and poxviruses, and its expression is upregulated in certain cancers, autoimmune disorders, and chronic inflammatory conditions. GZMH antibodies enable the detection of this protein in tissues or cells via techniques like Western blotting, immunohistochemistry, or flow cytometry, aiding investigations into its localization, expression patterns, and functional interactions. Recent studies also explore its potential as a biomarker for disease prognosis or therapeutic targeting. However, cross-reactivity with other granzymes and variability in antibody specificity require careful validation in experimental settings. Ongoing research aims to clarify GZMH's unique contributions to immune regulation and pathology.

       
关键字: GZMH抗体;GZMH;GZMH Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
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