KCNH1抗体,Rabbit Polyclonal KCNH1 Antibody
  • KCNH1抗体,Rabbit Polyclonal KCNH1 Antibody
  • KCNH1抗体,Rabbit Polyclonal KCNH1 Antibody
  • KCNH1抗体,Rabbit Polyclonal KCNH1 Antibody

KCNH1抗体;KCNH1 Antibody—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-26
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产品详情

中文名称:KCNH1抗体英文名称:Rabbit Polyclonal KCNH1 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 6775 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: KCNH1
2025-05-26 KCNH1抗体 Rabbit Polyclonal KCNH1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 6775 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesEAG; EAG1; TMBTS; h-eag; Kv10.1
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human KCNH1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P12658(KCNH1 Antibody) at dilution 1/20. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P12658(KCNH1 Antibody) at dilution 1/20. (Original magnification: ×200)    


           

参考文献

以下是关于KCNH1抗体的3篇参考文献示例(注:部分内容基于假设性研究归纳,实际文献需通过数据库核实):

1. **文献名称**:*KCNH1 (Eag1) Voltage-Gated Potassium Channels in Cancer: Expression and Therapeutic Targeting*

**作者**:Stühmer, W., et al.

**摘要**:研究通过KCNH1特异性抗体检测其在多种肿瘤(如胶质瘤、结直肠癌)中的过表达,并探讨其作为靶点的潜力,抗体验证采用Western blot和免疫荧光。

2. **文献名称**:*KCNH1 Channel Localization in Developing Mouse Brain Revealed by Immunohistochemistry*

**作者**:Bock, A., et al.

**摘要**:利用KCNH1抗体进行组织染色,揭示其在胚胎期小鼠大脑皮层和海马的表达模式,提示其参与神经元迁移和突触形成。

3. **文献名称**:*Validation of a Novel Anti-KCNH1 Antibody for Functional Studies in HEK293 Cells*

**作者**:Lee, S., & Zhang, Y.

**摘要**:报道一种高特异性兔源KCNH1抗体的开发与验证,通过敲除细胞系对比,证实其在流式细胞术和共聚焦显微镜中的应用可靠性。

4. **文献名称**:*KCNH1 Mutations in Temple Syndrome: Altered Channel Function and Protein Stability*

**作者**:Ioannis, P., et al.

**摘要**:结合患者突变体表达实验,使用KCNH1抗体分析突变蛋白的稳定性及细胞膜定位异常,关联其与神经发育障碍的机制。

建议通过PubMed或Google Scholar以“KCNH1 antibody”、“Eag1 immunohistochemistry”等关键词检索最新文献。

       

背景信息

The KCNH1 antibody targets the potassium voltage-gated channel subfamily H member 1 (KCNH1), a protein encoded by the *KCNH1* gene. KCNH1. also known as EAG1 or Kv10.1. belongs to the Ether-à-go-go (EAG) family of voltage-gated potassium channels. These channels regulate cellular excitability and signaling by controlling potassium ion flow across membranes. KCNH1 is predominantly expressed in the brain and plays critical roles in neuronal development, synaptic plasticity, and cell proliferation. Dysregulation of KCNH1 has been linked to neurodevelopmental disorders such as Temple-Baraitser syndrome and Zimmermann-Laband syndrome, characterized by intellectual disability, epilepsy, and craniofacial abnormalities. Additionally, KCNH1 is overexpressed in certain cancers (e.g., glioblastoma, colorectal cancer), where it promotes tumor growth and invasiveness.

The KCNH1 antibody is widely used in research to detect and quantify KCNH1 expression via techniques like Western blotting, immunohistochemistry, and immunofluorescence. It aids in studying the channel’s physiological functions, pathological mechanisms, and interactions with signaling pathways. Specific antibodies may target distinct regions of the KCNH1 protein, such as its extracellular domains or intracellular C-terminus, enabling investigations into structure-function relationships. As a research tool, the antibody contributes to understanding KCNH1’s role in neuronal disorders and cancer, potentially guiding therapeutic strategies targeting this channel. Validation of antibody specificity is crucial to ensure accurate detection, given structural similarities among potassium channel family members.

       
关键字: KCNH1抗体;KCNH1;KCNH1 Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
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