KNL1抗体,Rabbit Polyclonal KNL1 Antibody
  • KNL1抗体,Rabbit Polyclonal KNL1 Antibody
  • KNL1抗体,Rabbit Polyclonal KNL1 Antibody
  • KNL1抗体,Rabbit Polyclonal KNL1 Antibody

KNL1抗体;KNL1 Antibody—艾普蒂 新品

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-26
QQ交谈 微信洽谈

产品详情

中文名称:KNL1抗体英文名称:Rabbit Polyclonal KNL1 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 6792 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: KNL1
2025-05-26 KNL1抗体 Rabbit Polyclonal KNL1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 6792 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

产品详情

AliasesD40; CT29; Spc7; CASC5; MCPH4; hKNL-1; AF15Q14; PPP1R55; hSpc105
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human KNL1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

  •  

     

       The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P12702(KNL1 Antibody) at dilution 1/20. (Original magnification: ×200)    


  •  

     

       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P12702(KNL1 Antibody) at dilution 1/20. (Original magnification: ×200)    


           

参考文献

以下是关于KNL1抗体的3篇示例参考文献及其摘要概括(注:文献为示例性内容,实际引用请通过学术数据库核实):

---

1. **文献名称**: *"KNL1 is a key regulator of microtubule attachment and spindle checkpoint signaling"*

**作者**: Cheeseman, I.M., et al.

**摘要概括**: 该研究利用KNL1特异性抗体,通过免疫荧光和免疫印迹分析,揭示了KNL1在动粒介导的微管附着及纺锤体检查点信号传导中的核心作用。研究发现KNL1缺失导致染色体错误分离,并阐明了其与BUB1激酶的相互作用机制。

2. **文献名称**: *"Phosphorylation-dependent regulation of KNL1 in chromosome segregation fidelity"*

**作者**: Vleugel, M., et al.

**摘要概括**: 研究通过KNL1抗体检测磷酸化修饰,发现Aurora B激酶介导的KNL1磷酸化对维持染色体分离精度至关重要。实验结合RNA干扰和活细胞成像,表明磷酸化位点突变会破坏动粒-微管稳定性。

3. **文献名称**: *"Mutations in KNL1 cause primary microcephaly by disrupting mitotic progression"*

**作者**: Kiyomitsu, T., et al.

**摘要概括**: 该研究在小头畸形患者中发现KNL1基因突变,利用KNL1抗体进行免疫组化和蛋白质印迹,证实突变导致蛋白表达异常及有丝分裂延迟,揭示了KNL1在神经发育中的病理机制。

---

**备注**:

- 以上文献为基于KNL1相关研究的常见方向构造的示例,实际文献需通过PubMed、Google Scholar等平台以关键词“KNL1 antibody”“CASC5 immune localization”等检索。

- KNL1(又称CASC5)在癌症及遗传病中的研究可能涉及抗体应用,建议结合具体研究领域筛选文献。

       

背景信息

The KNL1 antibody is a crucial tool in studying the kinetochore-associated protein KNL1 (Kinetochore Null 1), also known as CASC5 (Cancer Susceptibility Candidate 5). KNL1 is a scaffold protein localized at the kinetochore, a multi-protein structure essential for proper chromosome segregation during mitosis and meiosis. It plays a pivotal role in the spindle assembly checkpoint (SAC), a surveillance mechanism ensuring accurate chromosome attachment to spindle microtubules before anaphase. KNL1 recruits other SAC components, such as BUB1 and BUBR1. and facilitates the assembly of checkpoint signaling complexes. Dysregulation of KNL1 is linked to chromosomal instability, mitotic errors, and diseases like cancer or developmental disorders.

KNL1 antibodies are widely used in research to investigate kinetochore dynamics, SAC function, and mitotic regulation. They enable detection of KNL1 expression via techniques like Western blotting, immunofluorescence, and immunoprecipitation, helping to elucidate its interaction networks and post-translational modifications. Studies using these antibodies have revealed KNL1's role in recruiting PP1 phosphatases to counteract Aurora B kinase activity, promoting stable microtubule attachments. Additionally, KNL1 mutations identified in human cancers and microcephaly-related syndromes highlight its clinical relevance. The antibody serves as a key reagent in both basic cell biology research and translational studies aiming to understand genome integrity mechanisms and develop therapeutic strategies targeting mitotic errors.

       
关键字: KNL1抗体;KNL1;KNL1 Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
询盘

KNL1抗体;KNL1 Antibody—艾普蒂相关厂家报价

产品名称 价格   公司名称 报价日期
询价
VIP4年
维百奥(北京)生物科技有限公司
2025-12-29
¥1800
VIP2年
费雪(杭州)医学研究有限公司
2026-01-05
询价
上海华盈生物医药科技有限公司
2025-12-28
内容声明:
以上所展示的信息由商家自行提供,内容的真实性、准确性和合法性由发布商家负责。 商家发布价格指该商品的参考价格,并非原价,该价格可能随着市场变化,或是由于您购买数量不同或所选规格不同而发生变化。最终成交价格,请咨询商家,以实际成交价格为准。请意识到互联网交易中的风险是客观存在的
主页 | 企业会员服务 | 广告业务 | 联系我们 | 旧版入口 | 中文MSDS | CAS Index | 常用化学品CAS列表 | 化工产品目录 | 新产品列表 |投诉中心
Copyright © 2008 ChemicalBook 京ICP备07040585号  京公海网安备110108000080号  All rights reserved.