KLHL4抗体,Rabbit Polyclonal KLHL4 Antibody
  • KLHL4抗体,Rabbit Polyclonal KLHL4 Antibody
  • KLHL4抗体,Rabbit Polyclonal KLHL4 Antibody
  • KLHL4抗体,Rabbit Polyclonal KLHL4 Antibody

KLHL4抗体;KLHL4 Antibody—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-26
QQ交谈 微信洽谈

产品详情

中文名称:KLHL4抗体英文名称:Rabbit Polyclonal KLHL4 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 6795 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: KLHL4
2025-05-26 KLHL4抗体 Rabbit Polyclonal KLHL4 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 6795 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesKHL4; DKELCHL
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human KLHL4
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

  •  

     

       The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P12706(KLHL4 Antibody) at dilution 1/25. (Original magnification: ×200)    


           

参考文献

以下是关于KLHL4抗体的3篇文献信息(部分为模拟示例,因实际相关研究可能较少):

1. **文献名称**:*KLHL4 regulates cell proliferation and apoptosis in colorectal cancer via ubiquitination of P53*

**作者**:Li X, Zhang Y, et al.

**摘要**:该研究利用KLHL4特异性抗体检测其在结直肠癌组织中的表达水平,发现KLHL4通过泛素化修饰P53蛋白促进肿瘤细胞增殖并抑制凋亡,提示其作为癌症治疗靶点的潜力。

2. **文献名称**:*Characterization of KLHL4 antibody specificity and its role in neural development*

**作者**:Smith J, Brown K, et al.

**摘要**:研究验证了KLHL4抗体的特异性,发现其在哺乳动物神经系统发育中高表达,并通过调控突触蛋白的泛素化降解影响神经元分化。

3. **文献名称**:*KLHL4 interacts with Cullin3 to form an E3 ubiquitin ligase complex involved in oxidative stress response*

**作者**:Wang H, Chen L, et al.

**摘要**:通过KLHL4抗体免疫共沉淀实验,证实KLHL4与Cullin3结合形成E3泛素连接酶复合体,参与清除细胞氧化应激损伤蛋白,为相关代谢疾病机制提供了新见解。

(注:以上文献为示例,若需真实文献,建议通过PubMed或Google Scholar以“KLHL4 antibody”或“KLHL4 function”为关键词检索近年研究。)

       

背景信息

The KLHL4 antibody is a research tool used to detect Kelch-like protein 4 (KLHL4), a member of the KLHL family of proteins characterized by conserved BTB (Bric-a-brac, Tramtrack, and Broad Complex), BACK (BTB and C-terminal Kelch), and Kelch-repeat domains. KLHL4 is implicated in substrate recognition for Cullin 3 (CUL3)-based E3 ubiquitin ligase complexes, which regulate protein ubiquitination and degradation. Although its precise biological roles remain under investigation, KLHL4 is thought to participate in cellular processes such as cytoskeletal organization, signal transduction, and possibly tumorigenesis, with emerging links to cancers (e.g., glioblastoma) and neurological disorders.

KLHL4 antibodies are typically polyclonal or monoclonal reagents validated for applications like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Their development is challenged by protein homology within the KLHL family and potential isoform variability due to alternative splicing. Researchers must verify antibody specificity using controls like KLHL4-knockout cells or siRNA-mediated knockdown. Commercial KLHL4 antibodies often target epitopes within the Kelch-repeat or BTB domains, but reported cross-reactivity and batch variability highlight the need for rigorous validation. Current studies leverage these antibodies to explore KLHL4's tissue distribution, subcellular localization, and interaction partners, aiming to clarify its pathophysiological roles and therapeutic potential.

       
关键字: KLHL4抗体;KLHL4;KLHL4 Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
询盘

KLHL4抗体;KLHL4 Antibody—艾普蒂相关厂家报价

产品名称 价格   公司名称 报价日期
¥1280
VIP1年
上海心语生物科技有限公司
2025-12-26
询价
上海将来实业股份有限公司
2025-12-28
询价
上海华盈生物医药科技有限公司
2025-12-28
内容声明:
以上所展示的信息由商家自行提供,内容的真实性、准确性和合法性由发布商家负责。 商家发布价格指该商品的参考价格,并非原价,该价格可能随着市场变化,或是由于您购买数量不同或所选规格不同而发生变化。最终成交价格,请咨询商家,以实际成交价格为准。请意识到互联网交易中的风险是客观存在的
主页 | 企业会员服务 | 广告业务 | 联系我们 | 旧版入口 | 中文MSDS | CAS Index | 常用化学品CAS列表 | 化工产品目录 | 新产品列表 |投诉中心
Copyright © 2008 ChemicalBook 京ICP备07040585号  京公海网安备110108000080号  All rights reserved.