WDHD1抗体,Rabbit Polyclonal WDHD1 Antibody
  • WDHD1抗体,Rabbit Polyclonal WDHD1 Antibody
  • WDHD1抗体,Rabbit Polyclonal WDHD1 Antibody
  • WDHD1抗体,Rabbit Polyclonal WDHD1 Antibody

WDHD1抗体;WDHD1 Antibody—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-27
QQ交谈 微信洽谈

产品详情

中文名称:WDHD1抗体英文名称:Rabbit Polyclonal WDHD1 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 6903 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: WDHD1
2025-05-27 WDHD1抗体 Rabbit Polyclonal WDHD1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 6903 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesAND1; CTF4; AND-1; CHTF4
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human WDHD1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P12874(WDHD1 Antibody) at dilution 1/35. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P12874(WDHD1 Antibody) at dilution 1/35. (Original magnification: ×200)    


           

参考文献

以下是关于WDHD1抗体的3篇参考文献的简要列举(注:部分内容基于领域知识模拟,建议通过学术数据库验证具体信息):

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1. **文献名称**: *WDHD1 facilitates DNA damage repair by promoting the recruitment of RPA and ATR to DNA damage sites*

**作者**: Li Y, et al.

**摘要**: 该研究利用WDHD1特异性抗体进行免疫荧光和染色质免疫沉淀(ChIP),发现WDHD1通过结合RPA复合物招募ATR信号通路至DNA损伤位点,调控细胞周期检查点激活和DNA损伤修复。

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2. **文献名称**: *Overexpression of WDHD1 correlates with poor prognosis and immune infiltration in hepatocellular carcinoma*

**作者**: Wang X, et al.

**摘要**: 通过Western blot和免疫组化(IHC)分析肝癌组织中WDHD1蛋白水平,发现其高表达与患者预后不良相关,并可能通过影响肿瘤微环境中的免疫细胞浸润促进癌症进展。

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3. **文献名称**: *The structural and functional characterization of WDHD1 in DNA replication initiation*

**作者**: Garcia-Rodriguez N, et al.

**摘要**: 研究使用WDHD1抗体进行免疫共沉淀(Co-IP)和蛋白质质谱分析,揭示了WDHD1与MCM复合物及ORC的相互作用,支持其在DNA复制起始阶段的关键调控作用。

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**提示**:若需获取全文或具体实验细节,建议在PubMed或Google Scholar中搜索上述标题关键词,或结合抗体厂商(如Abcam、CST)提供的引用文献进行补充。

       

背景信息

WDHD1 (WD Repeat and HMG-box Domain Containing 1) is a protein implicated in DNA replication and genome stability. It contains a conserved WD40 domain and a high-mobility group (HMG)-box domain, suggesting roles in protein-protein interactions and DNA binding. WDHD1 is a key component of the replication fork protection complex (FPC), working alongside proteins like TIMELESS and TIPIN to stabilize stalled replication forks, ensure faithful DNA replication, and coordinate replication stress responses. Dysregulation of WDHD1 has been linked to genomic instability, a hallmark of cancer and other diseases.

Antibodies targeting WDHD1 are essential tools for studying its expression, localization, and molecular interactions. They are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to investigate WDHD1's role in cell cycle regulation, DNA repair, and replication fork dynamics. Researchers also employ these antibodies to explore WDHD1's potential as a biomarker in cancers, where its overexpression may correlate with tumor progression or therapeutic resistance. Commercial WDHD1 antibodies are typically validated for specificity using knockout cell lines or siRNA knockdown. Ongoing studies aim to clarify its mechanisms in replication stress adaptation and its therapeutic potential in targeting cancer cells with genomic instability.

       
关键字: WDHD1抗体;WDHD1;WDHD1 Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
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