CAPS抗体,Rabbit Polyclonal CAPS Antibody
  • CAPS抗体,Rabbit Polyclonal CAPS Antibody
  • CAPS抗体,Rabbit Polyclonal CAPS Antibody
  • CAPS抗体,Rabbit Polyclonal CAPS Antibody

CAPS抗体;CAPS Antibody—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-28
QQ交谈 微信洽谈

产品详情

中文名称:CAPS抗体英文名称:Rabbit Polyclonal CAPS Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 7001 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: CAPS
2025-05-28 CAPS抗体 Rabbit Polyclonal CAPS Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 7001 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/20-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

产品详情

AliasesCAPS1
WB Predicted band size21 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human CAPS
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human pancreas tissue and Human kidney tissue lysates, Primary antibody: P13008(CAPS Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 90 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P13008(CAPS Antibody) at dilution 1/25. (Original magnification: ×200)    


           

参考文献

以下是3篇与CAPS(冷吡啉相关周期性综合征)抗体相关的文献摘要概括,供参考:

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1. **文献名称**:*Autoantibodies in cryopyrin-associated periodic syndromes*

**作者**:Goldbach-Mansky R, et al.

**摘要内容**:

本研究探讨CAPS患者血清中NLRP3蛋白自身抗体的检测意义,发现部分患者存在特异性抗体,可能与疾病活动性相关,为CAPS的免疫机制和诊断标志物提供新方向。

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2. **文献名称**:*Clinical and genetic characterization of cryopyrin-associated periodic syndrome*

**作者**:Hoffman HM, et al.

**摘要内容**:

文章系统分析CAPS患者的临床特征与基因突变(如NLRP3基因),指出部分患者体内存在炎性因子相关抗体,可能参与IL-1β通路异常激活,支持靶向抗体检测在分型中的应用。

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3. **文献名称**:*Anti-interleukin-1 therapy in CAPS patients: correlation with antibody profiles*

**作者**:Kuemmerle-Deschner JB, et al.

**摘要内容**:

通过研究CAPS患者接受IL-1抑制剂治疗后抗体水平的变化,发现治疗有效者血清中特定炎性抗体(如抗-IL-1β)显著降低,提示抗体动态可作为疗效监测指标。

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4. **文献名称**:*Autoinflammatory markers in pediatric CAPS: diagnostic implications*

**作者**:Gattorno M, et al.

**摘要内容**:

针对儿童CAPS患者的队列研究显示,血清抗NLRP3抗体的敏感性较低,但特异性较高,建议联合基因检测与抗体筛查以提高早期诊断准确性。

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**说明**:以上为模拟文献摘要,实际文献需通过PubMed/Google Scholar检索关键词(如“CAPS autoantibodies”“NLRP3 antibody”“cryopyrin-associated syndrome”)获取。

       

背景信息

CAPS antibodies, also called anti-caps antibodies, target the capsular polysaccharides (CAPS) of encapsulated bacteria like *Streptococcus pneumoniae* and *Haemophilus influenzae*. These antibodies play a critical role in adaptive immunity by binding to bacterial surface polysaccharides, promoting opsonization, phagocytosis, and complement-mediated clearance.

CAPS antibodies are primarily IgG, though IgM and IgA subtypes also contribute. Their production is T-cell-independent, relying on B-cell recognition of repetitive polysaccharide structures. This mechanism underpins the effectiveness of polysaccharide-based vaccines (e.g., pneumococcal vaccines), which stimulate long-term immune memory against specific serotypes.

Clinically, measuring CAPS antibody levels is vital for assessing immune competence, particularly in patients with recurrent infections or immunodeficiencies (e.g., common variable immunodeficiency). Low antibody titers post-vaccination may indicate impaired humoral immunity. However, CAPS antibody responses vary by age; young children and the elderly often exhibit weaker responses due to immune system immaturity or senescence.

Research continues to optimize CAPS-targeted vaccines and therapies, especially for high-risk populations. Understanding these antibodies also informs diagnostic strategies for bacterial infections and guides immunoglobulin replacement therapies in immunocompromised individuals.

       
关键字: CAPS抗体;CAPS;CAPS Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
询盘

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